Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives
Language: 
English
Abstract: 

The antimalarial compound qinghaosu (artemisinin) was tested in vitro for the ability to inhibit plaque formation by Toxoplasma gondii in fibroblasts. Qinghaosu at 0.4 microgram/ml for 5 days eliminated all plaques and microscopic foci of T. gondii. At 1.3 micrograms/ml for 14 days, qinghaosu completely eliminated T. gondii. Pretreatment of host cells or T. gondii with qinghaosu had no effect on T. gondii growth. There was no apparent toxicity to human fibroblasts in long-term studies. Of the six qinghaosu derivatives tested, dihydroqinghaosu, 1-propyl-ether-qinghaosu, and 1-butyl-ether-qinghaosu were comparable to qinghaosu. Ethyl-ether-qinghaosu (arteether) and sec-butyl-ether-qinghaosu were more effective. Methyl-ether-qinghaosu (artemether) was the most effective, with a potency approximately 10-fold greater than that of qinghaosu.

Author(s): 
Ke, O. Y.
Krug, E. C.
Marr, J. J.
Berens, R. L.
Item Type: 
Journal Article
Publication Title: 
Antimicrobial Agents and Chemotherapy
Journal Abbreviation: 
Antimicrob. Agents Chemother.
Publication Date: 
Oct-90
Publication Year: 
1990
Pages: 
1961-1965
Volume: 
34
Issue: 
10
ISSN: 
0066-4804
Library Catalog: 
PubMed
Extra: 
PMID: 2291661 PMCID: PMC171972

Turabian/Chicago Citation

O. Y. Ke, E. C. Krug, J. J. Marr and R. L. Berens. Oct-90. "Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives." Antimicrobial Agents and Chemotherapy 34: 10: 1961-1965.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0066-4804 | volume = 34 | pages = 1961-1965 | last = Ke | first = O. Y. | coauthors = Krug, E. C., Marr, J. J., Berens, R. L. | title = Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives | journal = Antimicrobial Agents and Chemotherapy | date = Oct-90 | pmid = | pmc = }} </ref>