Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis
Language: 
English
Abstract: 

The bioassay-directed isolation of Terminalia chebula fruits afforded four human immunodeficiency virus type 1 (HIV-1) integrase inhibitors, gallic acid ( 1) and three galloyl glucoses ( 2 - 4). In addition, four flavonol glycoside gallates ( 5 - 8) from Euphorbia pekinensis containing the galloyl moiety also showed the inhibitory activity at a level comparable to those of 2 - 4. By comparison with the activities of the compounds not bearing this moiety, it is proposed that the galloyl moiety plays a major role for inhibition against the 3'-processing of HIV-1 integrase of these compounds.

Author(s): 
Ahn, Mi-Jeong
Kim, Chul Young
Lee, Ji Suk
Kim, Tae Gyun
Kim, Seung Hee
Lee, Chong-Kyo
Lee, Bo-Bin
Shin, Cha-Gyun
Huh, Hoon
Kim, Jinwoong
Item Type: 
Journal Article
Publication Title: 
Planta Medica
Journal Abbreviation: 
Planta Med.
Publication Date: 
2002-05
Publication Year: 
2002
Pages: 
457-459
Volume: 
68
Issue: 
5
ISSN: 
0032-0943
DOI: 
10.1055/s-2002-32070
Library Catalog: 
PubMed
Extra: 
PMID: 12058327

Turabian/Chicago Citation

Mi-Jeong Ahn, Chul Young Kim, Ji Suk Lee, Tae Gyun Kim, Seung Hee Kim, Chong-Kyo Lee, Bo-Bin Lee, Cha-Gyun Shin, Hoon Huh and Jinwoong Kim. 2002-05. "Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis." Planta Medica 68: 5: 457-459. 10.1055/s-2002-32070.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1055/s-2002-32070 | issn = 0032-0943 | volume = 68 | pages = 457-459 | last = Ahn | first = Mi-Jeong | coauthors = Kim, Chul Young, Lee, Ji Suk, Kim, Tae Gyun, Kim, Seung Hee, Lee, Chong-Kyo, Lee, Bo-Bin, Shin, Cha-Gyun, Huh, Hoon, Kim, Jinwoong | title = Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis | journal = Planta Medica | date = 2002-05 | pmid = | pmc = }} </ref>