Inhibition of Th1 and Th17 Cells by Medicinal Plants and Their Derivatives: A Systematic Review
Language: 
English
Short Title: 
Inhibition of Th1 and Th17 Cells by Medicinal Plants and Their Derivatives
Abstract: 

Searching for new natural drugs that are capable of targeting Th1 and Th17 may lead to development of more effective treatments for inflammatory and autoimmune diseases. Most of the natural drugs can be derived from plants that are used in traditional medicine and folk medicine. The aim of this systematic review is to identify and introduce plants or plant derivatives that are effective on inflammatory diseases by inhibiting Th1 and Th17 responses. To achieve this purpose, the search terms herb, herbal medicine, herbal drug, medicinal plant, phytochemical, traditional Chinese medicine, Ayurvedic medicine, natural compound, inflammation, inflammatory diseases, Th1, Th17, T helper 1 or T helper 17 were used separately in Title/Keywords/Abstract in Web of Science and PubMed databases. In articles investigating the effect of the medicinal plants and their derivatives in inhibiting Th1 and Th17 cells, the effects of eight extracts of the medicinal plants, 21 plant-based compounds and some of their derivatives, and eight drugs derived from the medicinal plants' compounds in inhibiting Th1 and Th17 cells were reviewed. The results showed that medicinal plants and their derivates are able to suppress Th17 and Th1 T cell functions as well as cytokine secretion and differentiation. The results can be used to produce herbal drugs that suppress Th, especially Th17, responses. Copyright © 2017 John Wiley & Sons, Ltd.

Author(s): 
Asadi-Samani, Majid
Bagheri, Nader
Rafieian-Kopaei, Mahmoud
Shirzad, Hedayatollah
Item Type: 
Journal Article
Publication Title: 
Phytotherapy research: PTR
Journal Abbreviation: 
Phytother Res
Publication Date: 
2017-08
Publication Year: 
2017
Pages: 
1128-1139
Volume: 
31
Issue: 
8
ISSN: 
1099-1573
DOI: 
10.1002/ptr.5837
Library Catalog: 
PubMed
Extra: 
PMID: 28568565

Turabian/Chicago Citation

Majid Asadi-Samani, Nader Bagheri, Mahmoud Rafieian-Kopaei and Hedayatollah Shirzad. 2017-08. "Inhibition of Th1 and Th17 Cells by Medicinal Plants and Their Derivatives: A Systematic Review." Phytotherapy research: PTR 31: 8: 1128-1139. 10.1002/ptr.5837.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1002/ptr.5837 | issn = 1099-1573 | volume = 31 | pages = 1128-1139 | last = Asadi-Samani | first = Majid | coauthors = Bagheri, Nader, Rafieian-Kopaei, Mahmoud, Shirzad, Hedayatollah | title = Inhibition of Th1 and Th17 Cells by Medicinal Plants and Their Derivatives: A Systematic Review | journal = Phytotherapy research: PTR | date = 2017-08 | pmid = | pmc = }} </ref>