Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist
Language: 
English
Abstract: 

Androgen-dependent human LNCaP 104-S tumor xenografts progressed to androgen-independent relapsed tumors (104-Rrel) in athymic mice after castration. The growth of 104-Rrel tumors was suppressed by testosterone. However, 104-Rrel tumors adapted to androgen and regrew as androgen-stimulated 104-Radp tumors. Androgen receptor expression in tumors and serum prostate-specific antigen increased during progression from 104-S to 104-Rrel but decreased during transition from 104-Rrel to 104-Radp. Expression of genes related to liver X receptor (LXR) signaling changed during progression. LXRalpha, LXRbeta, ATP-binding cassette transporter A1 (ABCA1), and sterol 27-hydroxylase decreased during progression from 104-S to 104-Rrel. These coordinated changes in LXR signaling in mice during progression are consistent with our previous findings that reduction of ABCA1 gene expression stimulates proliferation of LNCaP cells. To test if attenuation of LXR signaling may enhance prostate cancer progression from an androgen-dependent state to an androgen-independent state, castrated mice carrying 104-S tumors were given the synthetic LXR agonist T0901317 by gavage. T0901317 delayed progression from 104-S to 104-Rrel tumors. Based on our in vivo model, androgen is beneficial for the treatment of androgen-independent androgen receptor-rich prostate cancer and modulation of LXR signaling may be a potentially useful therapy for prostate cancer.

Author(s): 
Chuu, Chih-Pin
Hiipakka, Richard A.
Kokontis, John M.
Fukuchi, Junichi
Chen, Rou-Yu
Liao, Shutsung
Item Type: 
Journal Article
Publication Title: 
Cancer Research
Journal Abbreviation: 
Cancer Res.
Publication Date: 
Jul 1, 2006
Publication Year: 
2006
Pages: 
6482-6486
Volume: 
66
Issue: 
13
ISSN: 
0008-5472
DOI: 
10.1158/0008-5472.CAN-06-0632
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 16818617

Turabian/Chicago Citation

Chih-Pin Chuu, Richard A. Hiipakka, John M. Kokontis, Junichi Fukuchi, Rou-Yu Chen and Shutsung Liao. Jul 1, 2006. "Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist." Cancer Research 66: 13: 6482-6486. 10.1158/0008-5472.CAN-06-0632.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1158/0008-5472.CAN-06-0632 | issn = 0008-5472 | volume = 66 | pages = 6482-6486 | last = Chuu | first = Chih-Pin | coauthors = Hiipakka, Richard A., Kokontis, John M., Fukuchi, Junichi, Chen, Rou-Yu, Liao, Shutsung | title = Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist | journal = Cancer Research | date = Jul 1, 2006 | pmid = | pmc = }} </ref>