Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis
Language: 
English
Abstract: 

We investigated the effects of the water soluble fraction of Terminalia chebula (Combretaceae) (WFTC) on systemic and local anaphylaxis. WFTC administered 1h before compound 48/80 injection inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.01-1.0 g/kg. When WFTC was administered 5 or 10 min after compound 48/80 injection, the mortality also decreased in a dose-dependent manner. Passive cutaneous anaphylaxis was inhibited by 63.5+/-7.8% by oral administration of WFTC (1.0 g/kg). When WFTC was pretreated at concentrations ranging from 0.005 to 1.0 g/kg, the serum histamine levels were reduced in a dose-dependent manner. WFTC (0.01-1.0 mg/ml) also significantly inhibited histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. However, WFTC (1.0 mg/ml) had a significant increasing effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha production from RPMC. These results indicate that WFTC may possess a strong antianaphylactic action.

Author(s): 
Shin, T. Y.
Jeong, H. J.
Kim, D. K.
Kim, S. H.
Lee, J. K.
Kim, D. K.
Chae, B. S.
Kim, J. H.
Kang, H. W.
Lee, C. M.
Lee, K. C.
Park, S. T.
Lee, E. J.
Lim, J. P.
Kim, H. M.
Lee, Y. M.
Item Type: 
Journal Article
Publication Title: 
Journal of Ethnopharmacology
Journal Abbreviation: 
J Ethnopharmacol
Publication Date: 
2001-02
Publication Year: 
2001
Pages: 
133-140
Volume: 
74
Issue: 
2
ISSN: 
0378-8741
Library Catalog: 
PubMed
Extra: 
PMID: 11167031

Turabian/Chicago Citation

T. Y. Shin, H. J. Jeong, D. K. Kim, S. H. Kim, J. K. Lee, D. K. Kim, B. S. Chae, J. H. Kim, H. W. Kang, C. M. Lee, K. C. Lee, S. T. Park, E. J. Lee, J. P. Lim, H. M. Kim and Y. M. Lee. 2001-02. "Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis." Journal of Ethnopharmacology 74: 2: 133-140.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0378-8741 | volume = 74 | pages = 133-140 | last = Shin | first = T. Y. | coauthors = Jeong, H. J., Kim, D. K., Kim, S. H., Lee, J. K., Kim, D. K., Chae, B. S., Kim, J. H., Kang, H. W., Lee, C. M., Lee, K. C., Park, S. T., Lee, E. J., Lim, J. P., Kim, H. M., Lee, Y. M. | title = Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis | journal = Journal of Ethnopharmacology | date = 2001-02 | pmid = | pmc = }} </ref>