The interaction between FOXO and SIRT1: tipping the balance towards survival
Language: 
English
Short Title: 
The interaction between FOXO and SIRT1
Abstract: 

When overexpressed, the NAD-dependent protein deacetylase Sir2 extends the lifespan of both budding yeast and the nematode worm Caenorhabditis elegans. In the worm, this extension of lifespan requires the FOXO transcription factor daf-16. Three recent articles focusing on mammalian homologues of Sir2 and FOXO have highlighted the mechanisms that generate this genetic interaction. Mammalian SIRT1 deacetylates FOXO3 and/or FOXO4, thus attenuating FOXO-induced apoptosis and potentiating FOXO-induced cell-cycle arrest. SIRT1 might increase longevity by shifting FOXO dependent responses away from cell death and towards cell survival.

Author(s): 
Giannakou, Maria E.
Partridge, Linda
Item Type: 
Journal Article
Publication Title: 
Trends in Cell Biology
Journal Abbreviation: 
Trends Cell Biol.
Publication Date: 
2004-08
Publication Year: 
2004
Pages: 
408-412
Volume: 
14
Issue: 
8
ISSN: 
0962-8924
DOI: 
10.1016/j.tcb.2004.07.006
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 15308206

Turabian/Chicago Citation

Maria E. Giannakou and Linda Partridge. 2004-08. "The interaction between FOXO and SIRT1: tipping the balance towards survival." Trends in Cell Biology 14: 8: 408-412. 10.1016/j.tcb.2004.07.006.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.tcb.2004.07.006 | issn = 0962-8924 | volume = 14 | pages = 408-412 | last = Giannakou | first = Maria E. | coauthors = Partridge, Linda | title = The interaction between FOXO and SIRT1: tipping the balance towards survival | journal = Trends in Cell Biology | date = 2004-08 | pmid = | pmc = }} </ref>