The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer
Language: 
English
Abstract: 

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. GH/Insulin/insulin-like growth factor-1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the corresponding genes increases lifespan in nematodes, fruit flies and mice. The life-prolonging effects of caloric restriction are likely related to decreasing IGF-1 levels. Evidence has emerged that antidiabetic drugs are promising candidates for both lifespan extension and prevention of cancer. Thus, antidiabetic drugs postpone spontaneous carcinogenesis in mice and rats, as well as chemical and radiation carcinogenesis in mice, rats and hamsters. Furthermore, metformin seems to decrease the risk for cancer in diabetic patients.

Author(s): 
Anisimov, Vladimir N.
Bartke, Andrzej
Item Type: 
Journal Article
Publication Title: 
Critical Reviews in Oncology/Hematology
Journal Abbreviation: 
Crit. Rev. Oncol. Hematol.
Publication Date: 
2013-09
Publication Year: 
2013
Pages: 
201-223
Volume: 
87
Issue: 
3
ISSN: 
1879-0461
DOI: 
10.1016/j.critrevonc.2013.01.005
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23434537 PMCID: PMC4095988

Turabian/Chicago Citation

Vladimir N. Anisimov and Andrzej Bartke. 2013-09. "The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer." Critical Reviews in Oncology/Hematology 87: 3: 201-223. 10.1016/j.critrevonc.2013.01.005.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.critrevonc.2013.01.005 | issn = 1879-0461 | volume = 87 | pages = 201-223 | last = Anisimov | first = Vladimir N. | coauthors = Bartke, Andrzej | title = The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer | journal = Critical Reviews in Oncology/Hematology | date = 2013-09 | pmid = | pmc = }} </ref>