Kleemeier award lecture: are there genes for aging?
Language: 
English
Short Title: 
Kleemeier award lecture
Abstract: 

The question of whether aging - the process that converts fit adults into frailer adults with a progressively increased risk of illness, injury, and death - is under genetic control is ambiguous, and its answer depends on what one means by aging. Natural selection can select for genes that retard aging, but only in species and niches where the value of prolonged survival outweighs its costs. Although the form aging takes can be affected by variations at many genetic loci the number of loci that moderate the pace of synchronized decay may be far smaller. Single gene mutants can extend mouse lifespan by over 50%, and genetic selection for small body size also leads to dramatic life span extension in dogs, suggesting strongly that aging can be affected by genetic variations within a species, but identification of genetic differences that discriminate long-lived from short-lived species will require a combination of genetic and physiological analyses.

Author(s): 
Miller, R. A.
Item Type: 
Journal Article
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Journal Abbreviation: 
J. Gerontol. A Biol. Sci. Med. Sci.
Publication Date: 
1999-07
Publication Year: 
1999
Pages: 
B297-307
Volume: 
54
Issue: 
7
ISSN: 
1079-5006
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 10462163

Turabian/Chicago Citation

R. A. Miller. 1999-07. "Kleemeier award lecture: are there genes for aging?." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 54: 7: B297-307.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1079-5006 | volume = 54 | pages = B297-307 | last = Miller | first = R. A. | coauthors = | title = Kleemeier award lecture: are there genes for aging? | journal = The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences | date = 1999-07 | pmid = | pmc = }} </ref>