Laboratory evaluation of the ict malaria P.f./P.v. immunochromatographic test for detecting the panmalarial antigen using a rodent malaria model
Language: 
English
Abstract: 

We evaluated the ICT Malaria P.f./P.v. immunochromatographic test for the detection of the panmalarial antigen (PMA) using a rodent malaria model. Mice were infected with Plasmodium berghei by mosquito bite, and blood was examined by microscopy and the ICT test. Treatment with artemether was started when the parasite density exceeded 70,000/microL. The ICT PMA band appeared when the parasite density was more than 2,000/microL, but it continued to be positive after the parasitemia became negative in response to the drug treatment. When all the test results were divided into increasing phase (IP) and declining phase (DP), the sensitivity in the DP was significantly higher than that in the IP, suggesting that the reactivity of the ICT PMA is significantly influenced by persistent and accumulated PMA after drug treatment and longer duration of infection in the DP. Recognizing that the patient population in a clinical situation would be a mixture of individuals in the IP and DP, it should be emphasized that the individual history of recent fever, duration of illness, and drug treatment must be considered carefully for the interpretation of the ICT results.

Author(s): 
Arai, Meiji
Ishii, Akira
Matsuoka, Hiroyuki
Item Type: 
Journal Article
Publication Title: 
The American Journal of Tropical Medicine and Hygiene
Journal Abbreviation: 
Am. J. Trop. Med. Hyg.
Publication Date: 
2/4/2015
Publication Year: 
2004
Pages: 
139-143
Volume: 
70
Issue: 
2
ISSN: 
0002-9637
Library Catalog: 
PubMed
Extra: 
PMID: 14993624

Turabian/Chicago Citation

Meiji Arai, Akira Ishii and Hiroyuki Matsuoka. 2/4/2015. "Laboratory evaluation of the ict malaria P.f./P.v. immunochromatographic test for detecting the panmalarial antigen using a rodent malaria model." The American Journal of Tropical Medicine and Hygiene 70: 2: 139-143.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0002-9637 | volume = 70 | pages = 139-143 | last = Arai | first = Meiji | coauthors = Ishii, Akira, Matsuoka, Hiroyuki | title = Laboratory evaluation of the ict malaria P.f./P.v. immunochromatographic test for detecting the panmalarial antigen using a rodent malaria model | journal = The American Journal of Tropical Medicine and Hygiene | date = 2/4/2015 | pmid = | pmc = }} </ref>