Leptin and anti-aging action of caloric restriction
Language: 
English
Abstract: 

Evolutional theories of aging and caloric restriction (CR) in animals predict the presence of neuroendocrine signals to divert the limited energy resources from energy-costly physiologic processes such as reproduction to those essential for survival in response to food shortage. The diversion of energy and subsequent molecular mechanisms might extend the lifespan. A growing body of evidence indicates that leptin, a peptide hormone secreted from adipocytes, has a key role in neuroendocrine adaptation against life-threatening stress such as fasting. The present review discusses the potential role of leptin in the anti-aging action of CR. Although several alternative signaling pathways might also mediate the anti-aging action of CR, leptin signaling could be a substantial pathway in the CR action. Research on neuroendocrine mechanisms of CR is warranted, because such efforts might provide clues to the regulation of the aging process in humans.

Author(s): 
Shimokawa, I.
Higami, Y.
Item Type: 
Journal Article
Publication Title: 
The Journal of Nutrition, Health & Aging
Journal Abbreviation: 
J Nutr Health Aging
Publication Date: 
2001
Publication Year: 
2001
Pages: 
43-48
Volume: 
5
Issue: 
1
ISSN: 
1279-7707
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 11250669

Turabian/Chicago Citation

I. Shimokawa and Y. Higami. 2001. "Leptin and anti-aging action of caloric restriction." The Journal of Nutrition, Health & Aging 5: 1: 43-48.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1279-7707 | volume = 5 | pages = 43-48 | last = Shimokawa | first = I. | coauthors = Higami, Y. | title = Leptin and anti-aging action of caloric restriction | journal = The Journal of Nutrition, Health & Aging | date = 2001 | pmid = | pmc = }} </ref>