Leptin signaling and aging: insight from caloric restriction
Language: 
English
Short Title: 
Leptin signaling and aging
Abstract: 

Organisms have evolved neuroendocrine and metabolic response systems to enhance survival during periods of food shortage, which occur frequently in nature. The anti-aging effect of caloric restriction (CR) might derive from these adaptive responses to maximize organism survival. The present article discusses the potential role for leptin, a hormone secreted from adipocytes, as a key signal that induces the adaptive responses relevant to CR. Evidence indicates that a CR-induced reduction of the plasma leptin concentration suppresses the gonadal, somatotropic, and thyroidal axes, and activates the adrenal axis. Metabolic adaptation, a shift in fuel utilization mainly conducted in the liver, seems to require leptin signaling. Although alternative signaling pathways might also mediate the anti-aging effects of CR, leptin signaling could be a substantial pathway involved in these effects. Molecular dissection of the mechanisms underlying the effects of CR will contribute to a better understanding of the aging process, leading to the extension of a healthy lifespan in humans.

Author(s): 
Shimokawa, I.
Higami, Y.
Item Type: 
Journal Article
Publication Title: 
Mechanisms of Ageing and Development
Journal Abbreviation: 
Mech. Ageing Dev.
Publication Date: 
9/30/2001
Publication Year: 
2001
Pages: 
1511-1519
Volume: 
122
Issue: 
14
ISSN: 
0047-6374
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 11511393

Turabian/Chicago Citation

I. Shimokawa and Y. Higami. 9/30/2001. "Leptin signaling and aging: insight from caloric restriction." Mechanisms of Ageing and Development 122: 14: 1511-1519.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0047-6374 | volume = 122 | pages = 1511-1519 | last = Shimokawa | first = I. | coauthors = Higami, Y. | title = Leptin signaling and aging: insight from caloric restriction | journal = Mechanisms of Ageing and Development | date = 9/30/2001 | pmid = | pmc = }} </ref>