Lifespan extension by caloric restriction: an aspect of energy metabolism
Language: 
English
Short Title: 
Lifespan extension by caloric restriction
Abstract: 

Caloric restriction (CR) may retard aging processes and extend lifespan in organisms by altering energy-metabolic pathways. In CR rodents, glucose influx into tissues is not reduced, as compared with control animals fed ad libitum (AL), although plasma concentrations of glucose and insulin are lower. Gene expression profiles in rodents have suggested that CR promotes gluconeogenesis and fatty acid biosynthesis in skeletal muscle. In the liver, CR promotes gluconeogenesis but decreases fatty acid synthesis and glycolysis. In lower organisms such as yeasts and nematodes, incomplete blocks in steps of insulin/insulin-like growth factor-1 (IGF-1) signal pathway extend lifespan. The life-prolonging effect of CR in yeasts requires NPT1 and SIR2 genes, both of which relate to sensing energy status and silencing genes. These findings stress the substantial role of energy metabolism on CR. Future studies on metabolic adaptation and gene silencing with regard to lower caloric intake will be warranted to understand the mechanisms of the anti-aging and life-prolonging effects of CR.

Author(s): 
Yamaza, Haruyoshi
Chiba, Takuya
Higami, Yoshikazu
Shimokawa, Isao
Item Type: 
Journal Article
Publication Title: 
Microscopy Research and Technique
Journal Abbreviation: 
Microsc. Res. Tech.
Publication Date: 
11/15/2002
Publication Year: 
2002
Pages: 
325-330
Volume: 
59
Issue: 
4
ISSN: 
1059-910X
DOI: 
10.1002/jemt.10212
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 12424796

Turabian/Chicago Citation

Haruyoshi Yamaza, Takuya Chiba, Yoshikazu Higami and Isao Shimokawa. 11/15/2002. "Lifespan extension by caloric restriction: an aspect of energy metabolism." Microscopy Research and Technique 59: 4: 325-330. 10.1002/jemt.10212.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1002/jemt.10212 | issn = 1059-910X | volume = 59 | pages = 325-330 | last = Yamaza | first = Haruyoshi | coauthors = Chiba, Takuya, Higami, Yoshikazu, Shimokawa, Isao | title = Lifespan extension by caloric restriction: an aspect of energy metabolism | journal = Microscopy Research and Technique | date = 11/15/2002 | pmid = | pmc = }} </ref>