Linking development and aging
Language: 
English
Abstract: 

Evolutionary theory predicts that the different life stages of organisms are coordinated to achieve maximal reproductive output. Moreover, aging can be seen as an evolutionary side effect of this selective process that applies to many living organisms. Hence, genetic, developmental, and physiological mechanisms resulting from this selection are expected to be conserved in diverse lineages. The insulin/insulin-like growth factor signaling (INS) pathway appears to be such a mechanism that regulates life span and reproduction in a variety of model organisms. Here I argue that the experimental tools of environmental manipulation and gene by environment interaction should be used more often both during the experimental organism's development and its adult life. This approach will help us to fully understand the functions of longevity-determining pathways and will determine the life stages during which these pathways exert their effects on adult life. These points are raised because of a recent Aging Cell publication by Tu and Tatar, in which the larval food environment was manipulated to determine the effects on adult reproduction, life span, aging, and INS. The results of this study are a promise of the usefulness of this approach for understanding the aging process.

Author(s): 
Zwaan, Bas J.
Item Type: 
Journal Article
Publication Title: 
Science of aging knowledge environment: SAGE KE
Journal Abbreviation: 
Sci Aging Knowledge Environ
Publication Date: 
11/26/2003
Publication Year: 
2003
Pages: 
pe32
Volume: 
2003
Issue: 
47
ISSN: 
1539-6150
DOI: 
10.1126/sageke.2003.47.pe32
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 14645858

Turabian/Chicago Citation

Bas J. Zwaan. 11/26/2003. "Linking development and aging." Science of aging knowledge environment: SAGE KE 2003: 47: pe32. 10.1126/sageke.2003.47.pe32.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1126/sageke.2003.47.pe32 | issn = 1539-6150 | volume = 2003 | pages = pe32 | last = Zwaan | first = Bas J. | coauthors = | title = Linking development and aging | journal = Science of aging knowledge environment: SAGE KE | date = 11/26/2003 | pmid = | pmc = }} </ref>