Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation
Language: 
English
Abstract: 

Covalent modifications of titanium with small molecules known to promote human osteoblast maturation are especially attractive in developing superior biomaterials. An important step in securing competent bone formation at implant sites is promoting the formation of mature osteoblasts, either from committed pre-osteoblasts or from their mesenchymal progenitors. To this end our research has focussed on identifying molecules that enhance human osteoblast formation and maturation and to develop ways of covalently attaching these molecules to implant surfaces so that they are more likely to withstand the rigors of the implantation process whilst still retaining their bioactivity. Herein we report the novel production of lipid-functionalised titanium using lysophosphatidic acid or a related compound, (3S) 1-fluoro-3-hydroxy-4-butyl-1-phosphonate. Both lipids were especially effective at co-operating with calcitriol to promote human osteoblast maturation at these modified Ti surfaces in vitro. The novel findings presented offer enticing new developments towards the fabrication of next-generation implant devices with the potential to significantly enhance the osseointegration process and with it improvements in future prosthesis performance and longevity.

Author(s): 
Mansell, Jason P.
Brown, Judith
Knapp, Jonathan G.
Faul, Charl F. J.
Blom, Ashley W.
Item Type: 
Journal Article
Publication Title: 
European Cells & Materials
Journal Abbreviation: 
Eur Cell Mater
Publication Date: 
2012
Publication Year: 
2012
Pages: 
348-361
Volume: 
23
ISSN: 
1473-2262
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22573454

Turabian/Chicago Citation

Jason P. Mansell, Judith Brown, Jonathan G. Knapp, Charl F. J. Faul and Ashley W. Blom. 2012. "Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation." European Cells & Materials 23: 348-361.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1473-2262 | volume = 23 | pages = 348-361 | last = Mansell | first = Jason P. | coauthors = Brown, Judith, Knapp, Jonathan G., Faul, Charl F. J., Blom, Ashley W. | title = Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation | journal = European Cells & Materials | date = 2012 | pmid = | pmc = }} </ref>