Mechanisms underlying epigenetic effects of early social experience: the role of neuropeptides and steroids
Language: 
English
Short Title: 
Mechanisms underlying epigenetic effects of early social experience
Abstract: 

In mammals the neonatal period is a time of significant social interaction. This is true even in solitary species as females spend a significant amount of time nursing and caring for their offspring. In social species interactions may also include the father, older siblings and extended family members. This period is a time of significant development, including organization of the central nervous system, and therefore a time when the degree and type of social interaction influences the development and expression of social behavior in adulthood. The purpose of this review is to examine the possible mechanisms for the epigenetic effects of early social experience on the subsequent expression of social behavior. We propose that social interactions during the neonatal period organize the subsequent expression of behavior by altering sensitivity to neuropeptides and steroids. Both neuropeptides (e.g. oxytocin and arginine vasopressin) and steroids (e.g. estrogen) regulate or influence the expression of behaviors such as affiliation, aggression, sociosexual behavior, parental behavior, and responses to stress. Therefore, changes in sensitivity to these hormones via reorganization of receptors or changes in hormone production and secretion are potentially powerful mechanisms through which early social experience can mold subsequent social behaviors.

Author(s): 
Cushing, Bruce S.
Kramer, Kristin M.
Item Type: 
Journal Article
Publication Title: 
Neuroscience and Biobehavioral Reviews
Journal Abbreviation: 
Neurosci Biobehav Rev
Publication Date: 
2005
Publication Year: 
2005
Pages: 
1089-1105
Volume: 
29
Issue: 
7
ISSN: 
0149-7634
DOI: 
10.1016/j.neubiorev.2005.04.001
Library Catalog: 
PubMed
Extra: 
PMID: 16099507

Turabian/Chicago Citation

Bruce S. Cushing and Kristin M. Kramer. 2005. "Mechanisms underlying epigenetic effects of early social experience: the role of neuropeptides and steroids." Neuroscience and Biobehavioral Reviews 29: 7: 1089-1105. 10.1016/j.neubiorev.2005.04.001.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.neubiorev.2005.04.001 | issn = 0149-7634 | volume = 29 | pages = 1089-1105 | last = Cushing | first = Bruce S. | coauthors = Kramer, Kristin M. | title = Mechanisms underlying epigenetic effects of early social experience: the role of neuropeptides and steroids | journal = Neuroscience and Biobehavioral Reviews | date = 2005 | pmid = | pmc = }} </ref>