Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents
Language: 
English
Abstract: 

Restriction of dietary methionine by 80% slows the progression of aged-related diseases and prolongs lifespan in rodents. A salient feature of the methionine restriction phenotype is the significant reduction of adipose tissue mass, which is associated with improvement of insulin sensitivity. These beneficial effects of MR involve a host of metabolic adaptations leading to increased mitochondrial biogenesis and function, elevated energy expenditure, changes of lipid and carbohydrate homeostasis, and decreased oxidative damage and inflammation. This review summarizes observations from MR studies and provides insight about potential mediators of tissue-specific responses associated with MR's favorable metabolic effects that contribute to health and lifespan extension.

Author(s): 
Perrone, Carmen E.
Malloy, Virginia L.
Orentreich, David S.
Orentreich, Norman
Item Type: 
Journal Article
Publication Title: 
Experimental Gerontology
Journal Abbreviation: 
Exp. Gerontol.
Publication Date: 
2013-07
Publication Year: 
2013
Pages: 
654-660
Volume: 
48
Issue: 
7
ISSN: 
1873-6815
DOI: 
10.1016/j.exger.2012.07.005
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22819757

Turabian/Chicago Citation

Carmen E. Perrone, Virginia L. Malloy, David S. Orentreich and Norman Orentreich. 2013-07. "Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents." Experimental Gerontology 48: 7: 654-660. 10.1016/j.exger.2012.07.005.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.exger.2012.07.005 | issn = 1873-6815 | volume = 48 | pages = 654-660 | last = Perrone | first = Carmen E. | coauthors = Malloy, Virginia L., Orentreich, David S., Orentreich, Norman | title = Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents | journal = Experimental Gerontology | date = 2013-07 | pmid = | pmc = }} </ref>