Metabolism, longevity and epigenetics
Language: 
English
Abstract: 

Metabolic homeostasis and interventions that influence nutrient uptake are well-established means to influence lifespan even in higher eukaryotes. Until recently, the molecular mechanisms explaining such an effect remained scantily understood. Sirtuins are a group of protein deacetylases that depend on the metabolic intermediate NAD(+) as a cofactor for their function. For this reason they sense metabolic stress and in turn function at multiple levels to exert proper metabolic adaptation. Among other things, sirtuins can perform as histone deacetylases inducing epigenetic changes to modulate transcription and DNA repair. Recent studies have indicated that beyond sirtuins, the activity of other chromatin modifiers, such as histone acetyl transferases, might also be tightly linked to the availability of their intermediate metabolite acetyl-CoA. We summarize current knowledge of the emerging concepts indicating close crosstalk between the epigenetic machineries able to sense metabolic stress, their adaptive metabolic responses and their potential role in longevity.

Author(s): 
Cosentino, Claudia
Mostoslavsky, Raul
Item Type: 
Journal Article
Publication Title: 
Cellular and molecular life sciences: CMLS
Journal Abbreviation: 
Cell. Mol. Life Sci.
Publication Date: 
2013-05
Publication Year: 
2013
Pages: 
1525-1541
Volume: 
70
Issue: 
9
ISSN: 
1420-9071
DOI: 
10.1007/s00018-013-1295-3
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23467663 PMCID: PMC3625512

Turabian/Chicago Citation

Claudia Cosentino and Raul Mostoslavsky. 2013-05. "Metabolism, longevity and epigenetics." Cellular and molecular life sciences: CMLS 70: 9: 1525-1541. 10.1007/s00018-013-1295-3.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s00018-013-1295-3 | issn = 1420-9071 | volume = 70 | pages = 1525-1541 | last = Cosentino | first = Claudia | coauthors = Mostoslavsky, Raul | title = Metabolism, longevity and epigenetics | journal = Cellular and molecular life sciences: CMLS | date = 2013-05 | pmid = | pmc = }} </ref>