Metformin improves healthspan and lifespan in mice

Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic. Treatment with metformin mimics some of the benefits of calorie restriction, such as improved physical performance, increased insulin sensitivity, and reduced low-density lipoprotein and cholesterol levels without a decrease in caloric intake. At a molecular level, metformin increases AMP-activated protein kinase activity and increases antioxidant protection, resulting in reductions in both oxidative damage accumulation and chronic inflammation. Our results indicate that these actions may contribute to the beneficial effects of metformin on healthspan and lifespan. These findings are in agreement with current epidemiological data and raise the possibility of metformin-based interventions to promote healthy aging.

Martin-Montalvo, Alejandro
Mercken, Evi M.
Mitchell, Sarah J.
Palacios, Hector H.
Mote, Patricia L.
Scheibye-Knudsen, Morten
Gomes, Ana P.
Ward, Theresa M.
Minor, Robin K.
Blouin, Marie-José
Schwab, Matthias
Pollak, Michael
Zhang, Yongqing
Yu, Yinbing
Becker, Kevin G.
Bohr, Vilhelm A.
Ingram, Donald K.
Sinclair, David A.
Wolf, Norman S.
Spindler, Stephen R.
Bernier, Michel
de Cabo, Rafael
Item Type: 
Journal Article
Publication Title: 
Nature Communications
Journal Abbreviation: 
Nat Commun
Publication Date: 
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 23900241 PMCID: PMC3736576

Turabian/Chicago Citation

Alejandro Martin-Montalvo, Evi M. Mercken, Sarah J. Mitchell, Hector H. Palacios, Patricia L. Mote, Morten Scheibye-Knudsen, Ana P. Gomes, Theresa M. Ward, Robin K. Minor, Marie-José Blouin, Matthias Schwab, Michael Pollak, Yongqing Zhang, Yinbing Yu, Kevin G. Becker, Vilhelm A. Bohr, Donald K. Ingram, David A. Sinclair, Norman S. Wolf, Stephen R. Spindler, Michel Bernier and Rafael de Cabo. 2013. "Metformin improves healthspan and lifespan in mice." Nature Communications 4: 2192. 10.1038/ncomms3192.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/ncomms3192 | issn = 2041-1723 | volume = 4 | pages = 2192 | last = Martin-Montalvo | first = Alejandro | coauthors = Mercken, Evi M., Mitchell, Sarah J., Palacios, Hector H., Mote, Patricia L., Scheibye-Knudsen, Morten, Gomes, Ana P., Ward, Theresa M., Minor, Robin K., Blouin, Marie-José, Schwab, Matthias, Pollak, Michael, Zhang, Yongqing, Yu, Yinbing, Becker, Kevin G., Bohr, Vilhelm A., Ingram, Donald K., Sinclair, David A., Wolf, Norman S., Spindler, Stephen R., Bernier, Michel, de Cabo, Rafael | title = Metformin improves healthspan and lifespan in mice | journal = Nature Communications | date = 2013 | pmid = | pmc = }} </ref>