Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius
Language: 
English
Abstract: 

To evaluate whether an aqueous seed extract of Terminalia chebula Retzius inhibited development of atopy in vivo, we used a 2,4-dinitrofluorobenzene (DNFB)-induced animal model of atopic symptoms to investigate the effects of the extract. We measured CD4+ cell numbers by hematoxylin and eosin (H&E) staining, and determined the expression levels of matrix metalloproteinase (MMP)-9, interleukin (IL)-31, and T-bet genes, in this animal model. The data showed that a Terminalia chebula extract (100 µg/ml) exhibited strong anti-atopic activity, mediating a 52% reduction in the immune response, as measured by thickness of ear swelling, and resulting in decreased eosinophil levels in adjacent skin tissue. Collectively, the results indicate that a Terminalia chebula seed extract has potential for alleviation of atopy-like symptoms induced by DNFB in the mouse.

Author(s): 
Nam, Dong-Yoon
Lee, Jin-Man
Heo, Jin-Chul
Lee, Sang-Han
Item Type: 
Journal Article
Publication Title: 
International Journal of Molecular Medicine
Journal Abbreviation: 
Int. J. Mol. Med.
Publication Date: 
2011-12
Publication Year: 
2011
Pages: 
1013-1018
Volume: 
28
Issue: 
6
ISSN: 
1791-244X
DOI: 
10.3892/ijmm.2011.792
Library Catalog: 
PubMed
Extra: 
PMID: 21901245

Turabian/Chicago Citation

Dong-Yoon Nam, Jin-Man Lee, Jin-Chul Heo and Sang-Han Lee. 2011-12. "Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius." International Journal of Molecular Medicine 28: 6: 1013-1018. 10.3892/ijmm.2011.792.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.3892/ijmm.2011.792 | issn = 1791-244X | volume = 28 | pages = 1013-1018 | last = Nam | first = Dong-Yoon | coauthors = Lee, Jin-Man, Heo, Jin-Chul, Lee, Sang-Han | title = Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius | journal = International Journal of Molecular Medicine | date = 2011-12 | pmid = | pmc = }} </ref>