Mitochondrial dysfunction in aging and longevity: a causal or protective role?
Language: 
English
Short Title: 
Mitochondrial dysfunction in aging and longevity
Abstract: 

SIGNIFICANCE: Among the most highly investigated theories of aging is the mitochondrial theory of aging. The basis of this theory includes a central role for altered or compromised mitochondrial function in the pathophysiologic declines associated with aging. In general, studies in various organisms, including nematodes, rodents, and humans, have largely upheld that aging is associated with mitochondrial dysfunction. However, results from a number of studies directly testing the mitochondrial theory of aging by modulating oxidant production or scavenging in vivo in rodents have generally been inconsistent with predictions of the theory. RECENT ADVANCES: Interestingly, electron transport chain mutations or deletions in invertebrates and mice that causes mitochondrial dysfunction paradoxically leads to enhanced longevity, further challenging the mitochondrial theory of aging. CRITICAL ISSUES: How can mitochondrial dysfunction contribute to lifespan extension in the mitochondrial mutants, and what does it mean for the mitochondrial theory of aging? FUTURE DIRECTIONS: It will be important to determine the potential mechanisms that lead to enhanced longevity in the mammalian mitochondrial mutants.

Author(s): 
Pulliam, Daniel A.
Bhattacharya, Arunabh
Van Remmen, Holly
Item Type: 
Journal Article
Publication Title: 
Antioxidants & Redox Signaling
Journal Abbreviation: 
Antioxid. Redox Signal.
Publication Date: 
10/20/2013
Publication Year: 
2013
Pages: 
1373-1387
Volume: 
19
Issue: 
12
ISSN: 
1557-7716
DOI: 
10.1089/ars.2012.4950
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23025472

Turabian/Chicago Citation

Daniel A. Pulliam, Arunabh Bhattacharya and Holly Van Remmen. 10/20/2013. "Mitochondrial dysfunction in aging and longevity: a causal or protective role?." Antioxidants & Redox Signaling 19: 12: 1373-1387. 10.1089/ars.2012.4950.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1089/ars.2012.4950 | issn = 1557-7716 | volume = 19 | pages = 1373-1387 | last = Pulliam | first = Daniel A. | coauthors = Bhattacharya, Arunabh, Van Remmen, Holly | title = Mitochondrial dysfunction in aging and longevity: a causal or protective role? | journal = Antioxidants & Redox Signaling | date = 10/20/2013 | pmid = | pmc = }} </ref>