Mitochondrial energy metabolism and ageing
Language: 
English
Abstract: 

Ageing can be defined as "a progressive, generalized impairment of function, resulting in an increased vulnerability to environmental challenge and a growing risk of disease and death". Ageing is likely a multifactorial process caused by accumulated damage to a variety of cellular components. During the last 20 years, gerontological studies have revealed different molecular pathways involved in the ageing process and pointed out mitochondria as one of the key regulators of longevity. Increasing age in mammals correlates with increased levels of mitochondrial DNA (mtDNA) mutations and a deteriorating respiratory chain function. Experimental evidence in the mouse has linked increased levels of somatic mtDNA mutations to a variety of ageing phenotypes, such as osteoporosis, hair loss, graying of the hair, weight reduction and decreased fertility. A mosaic respiratory chain deficiency in a subset of cells in various tissues, such as heart, skeletal muscle, colonic crypts and neurons, is typically found in aged humans. It has been known for a long time that respiratory chain-deficient cells are more prone to undergo apoptosis and an increased cell loss is therefore likely of importance in the age-associated mitochondrial dysfunction. In this review, we would like to point out the link between the mitochondrial energy balance and ageing, as well as a possible connection between the mitochondrial metabolism and molecular pathways important for the lifespan extension.

Author(s): 
Bratic, Ivana
Trifunovic, Aleksandra
Item Type: 
Journal Article
Publication Title: 
Biochimica Et Biophysica Acta
Journal Abbreviation: 
Biochim. Biophys. Acta
Publication Date: 
2010-07
Publication Year: 
2010
Pages: 
961-967
Volume: 
1797
Issue: 
7-Jun
ISSN: 
0006-3002
DOI: 
10.1016/j.bbabio.2010.01.004
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20064485

Turabian/Chicago Citation

Ivana Bratic and Aleksandra Trifunovic. 2010-07. "Mitochondrial energy metabolism and ageing." Biochimica Et Biophysica Acta 1797: 7-Jun: 961-967. 10.1016/j.bbabio.2010.01.004.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.bbabio.2010.01.004 | issn = 0006-3002 | volume = 1797 | pages = 961-967 | last = Bratic | first = Ivana | coauthors = Trifunovic, Aleksandra | title = Mitochondrial energy metabolism and ageing | journal = Biochimica Et Biophysica Acta | date = 2010-07 | pmid = | pmc = }} </ref>