Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent
Language: 
English
Short Title: 
Mitochondrial medicine
Abstract: 

The search for effective treatments that prevent oxidative stress associated with premature ageing and neurodegenerative diseases is an important area of neurochemical research. As age- and disease-related oxidative stress is frequently associated with mitochondrial dysfunction, amphiphilic antioxidant agents of high stability and selectivity that target these organelles can provide on-site protection. Such an amphiphilic nitrone protected human neuroblastoma cells at low micromolar concentrations against oxidative damage and death induced by exposure to the beta-amyloid peptide, hydrogen peroxide and 3-hydroxykynurenine. Daily administration of the antioxidant at a concentration of only 5 mum significantly increased the lifespan of the individually cultured rotifer Philodina acuticornis odiosa Milne. This compound is unique in its exceptional anti-ageing efficacy, being one order of magnitude more potent than any other compound previously tested on rotifers. The nitrone protected these aquatic animals against the lethal toxicity of hydrogen peroxide and doxorubicin and greatly enhanced their survival when co-administered with these oxidotoxins. These findings indicate that amphiphilic antioxidants have a great potential as neuroprotective agents in preventing the death of cells and organisms exposed to enhanced oxidative stress and damage.

Author(s): 
Poeggeler, Burkhard
Durand, GrÈgory
Polidori, Ange
Pappolla, Miguel A.
Vega-Naredo, Ignacio
Coto-Montes, Ana
Bˆker, Jutta
Hardeland, R¸diger
Pucci, Bernard
Item Type: 
Journal Article
Publication Title: 
Journal of Neurochemistry
Journal Abbreviation: 
J. Neurochem.
Publication Date: 
2005-11
Publication Year: 
2005
Pages: 
962-973
Volume: 
95
Issue: 
4
ISSN: 
0022-3042
DOI: 
10.1111/j.1471-4159.2005.03425.x
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 16135084

Turabian/Chicago Citation

Burkhard Poeggeler, GrÈgory Durand, Ange Polidori, Miguel A. Pappolla, Ignacio Vega-Naredo, Ana Coto-Montes, Jutta Bˆker, R¸diger Hardeland and Bernard Pucci. 2005-11. "Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent." Journal of Neurochemistry 95: 4: 962-973. 10.1111/j.1471-4159.2005.03425.x.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1111/j.1471-4159.2005.03425.x | issn = 0022-3042 | volume = 95 | pages = 962-973 | last = Poeggeler | first = Burkhard | coauthors = Durand, GrÈgory, Polidori, Ange, Pappolla, Miguel A., Vega-Naredo, Ignacio, Coto-Montes, Ana, Bˆker, Jutta, Hardeland, R¸diger, Pucci, Bernard | title = Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent | journal = Journal of Neurochemistry | date = 2005-11 | pmid = | pmc = }} </ref>