More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines
Language: 
English
Short Title: 
More tea for septic patients?
Abstract: 

Despite recent advances in antibiotic therapy and intensive care, sepsis remains widespread problems in critically ill patients. The high mortality of sepsis is in part mediated by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., TNF, IL-1, and IFN-gamma) and late (e.g., HMGB1) pro-inflammatory cytokines. In light of our recent discovery of HMGB1 as a late mediator of lethal systemic inflammation, and the observation that green tea (Camellia sinensis) dose-dependently attenuated bacterial endotoxin-induced HMGB1 release, we propose that regular tea intake might decrease the incidence of and mortality rates from lethal endotoxemia and sepsis.

Author(s): 
Chen, Xiaotian
Li, Wei
Wang, Haichao
Item Type: 
Journal Article
Publication Title: 
Medical Hypotheses
Journal Abbreviation: 
Med. Hypotheses
Publication Date: 
2006
Publication Year: 
2006
Pages: 
660-663
Volume: 
66
Issue: 
3
ISSN: 
0306-9877
DOI: 
10.1016/j.mehy.2005.09.025
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 16266789 PMCID: PMC1447554

Turabian/Chicago Citation

Xiaotian Chen, Wei Li and Haichao Wang. 2006. "More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines." Medical Hypotheses 66: 3: 660-663. 10.1016/j.mehy.2005.09.025.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.mehy.2005.09.025 | issn = 0306-9877 | volume = 66 | pages = 660-663 | last = Chen | first = Xiaotian | coauthors = Li, Wei, Wang, Haichao | title = More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines | journal = Medical Hypotheses | date = 2006 | pmid = | pmc = }} </ref>