Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
Language: 
English
Abstract: 

With ageing, there is a loss of adult stem cell function. However, there is no direct evidence that this has a causal role in ageing-related decline. We tested this using muscle-derived stem/progenitor cells (MDSPCs) in a murine progeria model. Here we show that MDSPCs from old and progeroid mice are defective in proliferation and multilineage differentiation. Intraperitoneal administration of MDSPCs, isolated from young wild-type mice, to progeroid mice confer significant lifespan and healthspan extension. The transplanted MDSPCs improve degenerative changes and vascularization in tissues where donor cells are not detected, suggesting that their therapeutic effect may be mediated by secreted factor(s). Indeed, young wild-type-MDSPCs rescue proliferation and differentiation defects of aged MDSPCs when co-cultured. These results establish that adult stem/progenitor cell dysfunction contributes to ageing-related degeneration and suggests a therapeutic potential of post-natal stem cells to extend health.

Author(s): 
Lavasani, Mitra
Robinson, Andria R.
Lu, Aiping
Song, Minjung
Feduska, Joseph M.
Ahani, Bahar
Tilstra, Jeremy S.
Feldman, Chelsea H.
Robbins, Paul D.
Niedernhofer, Laura J.
Huard, Johnny
Item Type: 
Journal Article
Publication Title: 
Nature Communications
Journal Abbreviation: 
Nat Commun
Publication Date: 
2012
Publication Year: 
2012
Pages: 
608
Volume: 
3
ISSN: 
2041-1723
DOI: 
10.1038/ncomms1611
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22215083 PMCID: PMC3272577

Turabian/Chicago Citation

Mitra Lavasani, Andria R. Robinson, Aiping Lu, Minjung Song, Joseph M. Feduska, Bahar Ahani, Jeremy S. Tilstra, Chelsea H. Feldman, Paul D. Robbins, Laura J. Niedernhofer and Johnny Huard. 2012. "Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model." Nature Communications 3: 608. 10.1038/ncomms1611.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/ncomms1611 | issn = 2041-1723 | volume = 3 | pages = 608 | last = Lavasani | first = Mitra | coauthors = Robinson, Andria R., Lu, Aiping, Song, Minjung, Feduska, Joseph M., Ahani, Bahar, Tilstra, Jeremy S., Feldman, Chelsea H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny | title = Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model | journal = Nature Communications | date = 2012 | pmid = | pmc = }} </ref>