The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions
Language: 
English
Abstract: 

Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid malignant tumours. We here in report that low dose of chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation. CA may thus be an effective and useful natural inhibitor of VEGFA mediated angiogenesis.

Author(s): 
Lu, Kai
Basu, Sujit
Item Type: 
Journal Article
Publication Title: 
Scientific Reports
Journal Abbreviation: 
Sci Rep
Publication Date: 
4/10/2015
Publication Year: 
2015
Pages: 
9642
Volume: 
5
ISSN: 
2045-2322
DOI: 
10.1038/srep09642
Library Catalog: 
PubMed
Extra: 
PMID: 25859636 PMCID: PMC4819393

Turabian/Chicago Citation

Kai Lu and Sujit Basu. 4/10/2015. "The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions." Scientific Reports 5: 9642. 10.1038/srep09642.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/srep09642 | issn = 2045-2322 | volume = 5 | pages = 9642 | last = Lu | first = Kai | coauthors = Basu, Sujit | title = The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions | journal = Scientific Reports | date = 4/10/2015 | pmid = | pmc = }} </ref>