Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review
Language: 
English
Short Title: 
Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy
Abstract: 

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side-effect without any FDA-approved treatment option. Prior reviews focus mostly on pharmacological interventions, but nonpharmaceutical interventions have also been evaluated. A Web of Science and PubMed database search to identify relevant RCTs from January 2005 to May 2015 included the terms: CIPN, cancer; and supplements, vitamin E, goshajinkigan, kampo, acetyl-L-carnitine, carnitine, alpha-lipoic acid, omega-3, glutamine, or glutamate; or massage, acupuncture, mind-body practice, yoga, meditation, Tai-Chi, physical activity, or exercise. Of 1465 publications screened, 12 RCTs evaluated natural products and one evaluated electroacupuncture. Vitamin E may help prevent CIPN. L-Glutamine, goshajinkigan, and omega-3 are also promising. Acetyl-L-carnitine may worsen CIPN and alpha-lipoic acid activity is unknown. Electroacupuncture was not superior to placebo. No RCTs were published regarding other complementary therapies, although some studies mention positive incidental findings. Natural products and complementary therapies deserve further investigation, given the lack of effective CIPN interventions.

Author(s): 
Brami, Cloé
Bao, Ting
Deng, Gary
Item Type: 
Journal Article
Publication Title: 
Critical Reviews in Oncology/Hematology
Journal Abbreviation: 
Crit. Rev. Oncol. Hematol.
Publication Date: 
2016-02
Publication Year: 
2016
Pages: 
325-334
Volume: 
98
ISSN: 
1879-0461
DOI: 
10.1016/j.critrevonc.2015.11.014
Library Catalog: 
PubMed
Extra: 
PMID: 26652982 PMCID: PMC4727999

Turabian/Chicago Citation

Cloé Brami, Ting Bao and Gary Deng. 2016-02. "Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review." Critical Reviews in Oncology/Hematology 98: 325-334. 10.1016/j.critrevonc.2015.11.014.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.critrevonc.2015.11.014 | issn = 1879-0461 | volume = 98 | pages = 325-334 | last = Brami | first = Cloé | coauthors = Bao, Ting, Deng, Gary | title = Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review | journal = Critical Reviews in Oncology/Hematology | date = 2016-02 | pmid = | pmc = }} </ref>