Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span
Language: 
English
Abstract: 

As part of an effort to review current understanding of the mechanisms by which caloric restriction (CR) extends maximum life span, the authors of the present review were requested to develop a list of key issues concerning the potential role of neuroendocrine systems in mediating these effects. It has long been hypothesized that failure of specific neuroendocrine functions during aging leads to key age-related systemic and physiological failures, and more recently it has been postulated that physiological neuroendocrine responses to CR may increase life span. However, although the acute neuroendocrine responses to fasting have been well studied, it is not clear that these responses are necessarily identical to those observed in response to the chronic moderate (30% to 50% reduction) CR that increases maximum life span. Therefore the recommendations of this panel fall into two categories. First, further characterization of neuroendocrine responses to CR over the entire life span is needed. Second, rigorous interventional studies are needed to test the extent to which neuroendocrine responses to CR mediate the effects of CR on life span, or alternatively if CR protects the function of essential neuroendocrine cells whose impairment reduces life span. Complementary studies using rodent models, nonhuman primates, and humans will be essential to assess the generality of elucidated mechanisms, and to determine if such mechanisms might apply to humans.

Author(s): 
Mobbs, C. V.
Bray, G. A.
Atkinson, R. L.
Bartke, A.
Finch, C. E.
Maratos-Flier, E.
Crawley, J. N.
Nelson, J. F.
Item Type: 
Journal Article
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Journal Abbreviation: 
J. Gerontol. A Biol. Sci. Med. Sci.
Publication Date: 
2001-03
Publication Year: 
2001
Pages: 
34-44
Volume: 
56 Spec No 1
ISSN: 
1079-5006
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 12088210

Turabian/Chicago Citation

C. V. Mobbs, G. A. Bray, R. L. Atkinson, A. Bartke, C. E. Finch, E. Maratos-Flier, J. N. Crawley and J. F. Nelson. 2001-03. "Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 56 Spec No 1: 34-44.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1079-5006 | volume = 56 Spec No 1 | pages = 34-44 | last = Mobbs | first = C. V. | coauthors = Bray, G. A., Atkinson, R. L., Bartke, A., Finch, C. E., Maratos-Flier, E., Crawley, J. N., Nelson, J. F. | title = Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span | journal = The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences | date = 2001-03 | pmid = | pmc = }} </ref>