New insights into the role of anabolic interventions in dialysis patients with protein energy wasting
Language: 
English
Abstract: 

PURPOSE OF REVIEW: Patients on maintenance dialysis commonly develop protein-energy wasting (PEW), which is associated with poor survival. There have been several advances in anabolic interventions aimed at improving PEW in these patients in recent years. RECENT FINDINGS: Oral or parenteral nutritional supplementation, especially if administered during dialysis, improves net protein anabolism in chronic hemodialysis patients. These beneficial effects have been extended to long-term benefits in recent clinical trials. Resistance exercise, alone or combined with intradialytic oral nutrition supplementation, also improves net protein balance in the acute setting although recent studies indicated a limited beneficial effect of long-term exercise alone on muscle protein accretion in chronic hemodialysis patients. Anabolic agents such as growth hormone and androgens have been shown to exert significant benefits on visceral protein stores, muscle mass and strength. Ghrelin, a hormone with combined orexigenic and anti-inflammatory effects, is a potential new nutritional intervention in maintenance dialysis patients. SUMMARY: Existing anabolic therapeutic strategies have proven to be effective in improving PEW in maintenance dialysis patients. Combined anabolic interventions and several new and established anabolic hormones represent further promising nutritional interventions. Large-scale randomized controlled trials examining the effects of anabolic interventions on mortality and morbidity are still lacking.

Author(s): 
Dong, Jie
Ikizler, T. Alp
Item Type: 
Journal Article
Publication Title: 
Current Opinion in Nephrology and Hypertension
Journal Abbreviation: 
Curr. Opin. Nephrol. Hypertens.
Publication Date: 
Nov 2009
Publication Year: 
2009
Pages: 
469-475
Volume: 
18
Issue: 
6
ISSN: 
1473-6543
DOI: 
10.1097/MNH.0b013e328331489d
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 19713839 PMCID: PMC2891019

Turabian/Chicago Citation

Jie Dong and T. Alp Ikizler. Nov 2009. "New insights into the role of anabolic interventions in dialysis patients with protein energy wasting." Current Opinion in Nephrology and Hypertension 18: 6: 469-475. 10.1097/MNH.0b013e328331489d.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1097/MNH.0b013e328331489d | issn = 1473-6543 | volume = 18 | pages = 469-475 | last = Dong | first = Jie | coauthors = Ikizler, T. Alp | title = New insights into the role of anabolic interventions in dialysis patients with protein energy wasting | journal = Current Opinion in Nephrology and Hypertension | date = Nov 2009 | pmid = | pmc = }} </ref>