No association of CETP genotype with cognitive function or age-related cognitive change
Language: 
English
Abstract: 

A cholesteryl ester transfer protein (CETP) genotype (V/V homozygosity for I405V, NCBI dbSNP rs5882) has been associated with preservation of cognitive function in old age, in addition to its associations with exceptional longevity and cardiovascular disease. We tested the hypotheses that this polymorphism was associated with either level of cognitive function or lifetime cognitive change in 525 participants who took part in the Scottish Mental Survey of 1932. Participants took the same well-validated mental ability test at ages 11 and 79. Scores were also available for several other mental ability tests at age 79, and history of cardiovascular disease was available. Frequency of the V/I genotype was slightly greater than expected in the sample, possibly consistent with some role for the V polymorphism in longevity, and the V/V genotype was associated with a lower rate of cardiovascular disease history. There were, however, no significant associations of CETP genotype with either childhood IQ or current cognitive function in old age, or with lifetime change in cognitive function.

Author(s): 
Johnson, Wendy
Harris, Sarah E.
Collins, Patrick
Starr, John M.
Whalley, Lawrence J.
Deary, Ian J.
Item Type: 
Journal Article
Publication Title: 
Neuroscience Letters
Journal Abbreviation: 
Neurosci. Lett.
Publication Date: 
6/13/2007
Publication Year: 
2007
Pages: 
189-192
Volume: 
420
Issue: 
2
ISSN: 
0304-3940
DOI: 
10.1016/j.neulet.2007.05.013
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 17531380

Turabian/Chicago Citation

Wendy Johnson, Sarah E. Harris, Patrick Collins, John M. Starr, Lawrence J. Whalley and Ian J. Deary. 6/13/2007. "No association of CETP genotype with cognitive function or age-related cognitive change." Neuroscience Letters 420: 2: 189-192. 10.1016/j.neulet.2007.05.013.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.neulet.2007.05.013 | issn = 0304-3940 | volume = 420 | pages = 189-192 | last = Johnson | first = Wendy | coauthors = Harris, Sarah E., Collins, Patrick, Starr, John M., Whalley, Lawrence J., Deary, Ian J. | title = No association of CETP genotype with cognitive function or age-related cognitive change | journal = Neuroscience Letters | date = 6/13/2007 | pmid = | pmc = }} </ref>