A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24 (-) B cells in centenarian offspring and elderly people
Language: 
English
Short Title: 
A novel B cell population revealed by a CD38/CD24 gating strategy
Abstract: 

The B cell arm of adaptive immunity undergoes significant modifications with age. Elderly people are characterized by impaired B cell responses reflected in a reduced ability to effectively respond against viruses and bacteria. Alterations of immunity with advancing age (immunosenescence) have been widely studied in centenarians who are considered a good example of successful aging. In recent years, attention has shifted to centenarian offspring (CO) as a model of people genetically advantaged for healthy aging and longevity. Here, we describe the preliminary characterization of a proposed new population of memory B cells, defined as CD19(+)CD38(-)CD24(-), which we find at higher frequencies in the elderly but less so in CO than healthy age-matched random controls. In addition, we found a decreased expression of RP105 (CD180), a toll-like receptor-associated molecule, on these cells. CD180 downregulation may potentially be a marker of immunosenescence. Moreover, we show that these CD19(+)CD38(-)CD24(-) B cells produce TNF and hypothesize that their observed expansion in the elderly might contribute to the increased inflammatory status sometimes designated "inflamm-aging."

Author(s): 
Buffa, Silvio
PellicanÚ, Mariavaleria
Bulati, Matteo
Martorana, Adriana
Goldeck, David
Caruso, Calogero
Pawelec, Graham
Colonna-Romano, Giuseppina
Item Type: 
Journal Article
Publication Title: 
Age (Dordrecht, Netherlands)
Journal Abbreviation: 
Age (Dordr)
Publication Date: 
2013-10
Publication Year: 
2013
Pages: 
2009-2024
Volume: 
35
Issue: 
5
ISSN: 
1574-4647
DOI: 
10.1007/s11357-012-9488-5
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23129025 PMCID: PMC3776115

Turabian/Chicago Citation

Silvio Buffa, Mariavaleria PellicanÚ, Matteo Bulati, Adriana Martorana, David Goldeck, Calogero Caruso, Graham Pawelec and Giuseppina Colonna-Romano. 2013-10. "A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24 (-) B cells in centenarian offspring and elderly people." Age (Dordrecht, Netherlands) 35: 5: 2009-2024. 10.1007/s11357-012-9488-5.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s11357-012-9488-5 | issn = 1574-4647 | volume = 35 | pages = 2009-2024 | last = Buffa | first = Silvio | coauthors = PellicanÚ, Mariavaleria, Bulati, Matteo, Martorana, Adriana, Goldeck, David, Caruso, Calogero, Pawelec, Graham, Colonna-Romano, Giuseppina | title = A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24 (-) B cells in centenarian offspring and elderly people | journal = Age (Dordrecht, Netherlands) | date = 2013-10 | pmid = | pmc = }} </ref>