Nutritional modulators of bone remodeling during aging

Bone mass declines progressively with age in both men and women from the age of approximately 30 y. Increased longevity will inevitability be associated with an increase in the incidence of osteoporosis, its associated complications, and incurred health care costs. Current pharmacologic approaches focus on inhibiting bone resorption in those with osteoporosis but do little to improve bone mass. Increased understanding of the cellular events responsible for normal bone formation has led to multiple pathways that can be targeted to positively influence bone mass. Bone morphogenetic proteins (BMPs) have been shown to stimulate bone formation, and the BMP2 gene was recently linked to osteoporosis. BMP-2 therefore represents one potential molecular target to identify new agents to simulate bone formation. Research is accumulating on the positive effects of dietary sources that stimulate the BMP2 promoter and their effects on bone formation. Flavonoids and statins occur naturally in food products and have been shown to promote bone formation. It may be possible to influence peak bone mass by dietary means and to decrease the risk of osteoporosis in later life. To ease the future burden of osteoporosis, focusing on prevention will be key, and this could include dietary interventions to stimulate bone formation.

Mundy, Gregory R.
Item Type: 
Journal Article
Publication Title: 
The American Journal of Clinical Nutrition
Journal Abbreviation: 
Am. J. Clin. Nutr.
Publication Date: 
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 16470007

Turabian/Chicago Citation

Gregory R. Mundy. 2006-02. "Nutritional modulators of bone remodeling during aging." The American Journal of Clinical Nutrition 83: 2: 427S-430S.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0002-9165 | volume = 83 | pages = 427S-430S | last = Mundy | first = Gregory R. | coauthors = | title = Nutritional modulators of bone remodeling during aging | journal = The American Journal of Clinical Nutrition | date = 2006-02 | pmid = | pmc = }} </ref>