?-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction
Language: 
English
Short Title: 
?-opioid receptor/dynorphin system
Abstract: 

Addictions to cocaine or heroin/prescription opioids [short-acting ?-opioid receptor (MOPr) agonists] involve relapsing cycles, with experimentation/escalating use, withdrawal/abstinence, and relapse/re-escalation. ?-Opioid receptors (KOPr; encoded by OPRK1), and their endogenous agonists, the dynorphins (encoded by PDYN), have counter-modulatory effects on reward caused by cocaine or MOPr agonist exposure, and exhibit plasticity in addictive-like states. KOPr/dynorphin activation is implicated in depression/anxiety, often comorbid with addictions. In this opinion article we propose that particular stages of the addiction cycle are differentially affected by KOPr/dynorphin systems. Vulnerability and resilience can be due to pre-existing (e.g., genetic) factors, or epigenetic modifications of the OPRK1 or PDYN genes during the addiction cycle. Pharmacotherapeutic approaches limiting changes in KOPr/dynorphin tone, especially with KOPr partial agonists, may hold potential for the treatment of specific drug addictions and psychiatric comorbidity.

Author(s): 
Butelman, Eduardo R.
Yuferov, Vadim
Kreek, Mary Jeanne
Item Type: 
Journal Article
Publication Title: 
Trends in Neurosciences
Journal Abbreviation: 
Trends Neurosci.
Publication Date: 
2012-10
Publication Year: 
2012
Pages: 
587-596
Volume: 
35
Issue: 
10
ISSN: 
1878-108X
DOI: 
10.1016/j.tins.2012.05.005
Library Catalog: 
PubMed
Extra: 
PMID: 22709632 PMCID: PMC3685470

Turabian/Chicago Citation

Eduardo R. Butelman, Vadim Yuferov and Mary Jeanne Kreek. 2012-10. "?-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction." Trends in Neurosciences 35: 10: 587-596. 10.1016/j.tins.2012.05.005.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.tins.2012.05.005 | issn = 1878-108X | volume = 35 | pages = 587-596 | last = Butelman | first = Eduardo R. | coauthors = Yuferov, Vadim, Kreek, Mary Jeanne | title = ?-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction | journal = Trends in Neurosciences | date = 2012-10 | pmid = | pmc = }} </ref>