Opioidergic orofacial antinociception induced by electroacupuncture at acupoint St36
Language: 
English
Abstract: 

The participation of opioids in the antinociceptive effect of electroacupuncture was evaluated in terms of nociception produced by thermal stimuli applied to the face of male Wistar rats, weighing 180-230 g. Electrical stimulation (bipolar and asymmetric square wave with 0.5 mA intensity for 20 min) of acupoint St36, located in the anterior tibial muscle 10 mm distal to the knee joint, induced antinociception in the present model, which was maintained for 150 min. Acupoint LI4, located in the junction of the first and second metacarpal bones, did not achieve antinociception at any frequency studied (5 Hz: 1.7 +/- 0.1; 30 Hz: 1.8 +/- 0.1; 100 Hz: 1.7 +/- 0.1 vs 1.4 +/- 0.2). The antinociception obtained by stimulation of acupoint St36 was only achieved when high frequency 100 Hz (3.0 +/- 0.2 vs 1.0 +/- 0.1) was used, and not with 5 or 30 Hz (1.2 +/- 0.2 and 0.7 +/- 0.1 vs 1.0 +/- 0.1). The antinociceptive effect of acupuncture occurred by opioid pathway activation, since naloxone (1 and 2 mg/kg, subcutaneously) antagonized it (1.8 +/- 0.2 and 1.7 +/- 0.2 vs 3.0 +/- 0.1).

Author(s): 
Almeida, R. T.
Perez, A. C.
Francischi, J. N.
Castro, M. S.
Duarte, I. D. G.
Item Type: 
Journal Article
Publication Title: 
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
Journal Abbreviation: 
Braz. J. Med. Biol. Res.
Publication Date: 
Jul 2008
Publication Year: 
2008
Pages: 
621-626
Volume: 
41
Issue: 
7
ISSN: 
1414-431X
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18641795

Turabian/Chicago Citation

R. T. Almeida, A. C. Perez, J. N. Francischi, M. S. Castro and I. D. G. Duarte. Jul 2008. "Opioidergic orofacial antinociception induced by electroacupuncture at acupoint St36." Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.] 41: 7: 621-626.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1414-431X | volume = 41 | pages = 621-626 | last = Almeida | first = R. T. | coauthors = Perez, A. C., Francischi, J. N., Castro, M. S., Duarte, I. D. G. | title = Opioidergic orofacial antinociception induced by electroacupuncture at acupoint St36 | journal = Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.] | date = Jul 2008 | pmid = | pmc = }} </ref>