Osteoarthritis: new insights. Part 2: treatment approaches
Language: 
English
Short Title: 
Osteoarthritis
Abstract: 

Osteoarthritis is the most common form of arthritis, affecting millions of people in the United States. It is a complex disease whose etiology bridges biomechanics and biochemistry. Evidence is growing for the role of systemic factors, such as genetics, diet, estrogen use, and bone density, and local biomechanical factors, such as muscle weakness, obesity, and joint laxity. These risk factors are particularly important in the weight-bearing joints, and modifying them may help prevent osteoarthritis-related pain and disability. Major advances in management to reduce pain and disability are yielding a panoply of available treatments ranging from nutriceuticals to chondrocyte transplantation, new oral anti-inflammatory medications, and health education. This article is part 2 of a two-part summary of a National Institutes of Health conference that brought together experts in osteoarthritis from diverse backgrounds and provided a multidisciplinary and comprehensive summary of recent advances in the prevention of osteoarthritis onset, progression, and disability. Part 2 focuses on treatment approaches; evidence for the efficacy of commonly used oral therapies is reviewed and information on alternative therapies, including nutriceuticals and acupuncture, is presented. Biomechanical interventions, such as exercise and bracing, and behavioral interventions directed toward enhancing self-management are reviewed. Current surgical approaches are described and probable future biotechnology-oriented approaches to treatment are suggested.

Author(s): 
Felson, D. T.
Lawrence, R. C.
Hochberg, M. C.
McAlindon, T.
Dieppe, P. A.
Minor, M. A.
Blair, S. N.
Berman, B. M.
Fries, J. F.
Weinberger, M.
Lorig, K. R.
Jacobs, J. J.
Goldberg, V.
Item Type: 
Journal Article
Publication Title: 
Annals of Internal Medicine
Journal Abbreviation: 
Ann. Intern. Med.
Publication Date: 
11/7/2000
Publication Year: 
2000
Pages: 
726-737
Volume: 
133
Issue: 
9
ISSN: 
0003-4819
Library Catalog: 
PubMed
Extra: 
PMID: 11074906

Turabian/Chicago Citation

D. T. Felson, R. C. Lawrence, M. C. Hochberg, T. McAlindon, P. A. Dieppe, M. A. Minor, S. N. Blair, B. M. Berman, J. F. Fries, M. Weinberger, K. R. Lorig, J. J. Jacobs and V. Goldberg. 11/7/2000. "Osteoarthritis: new insights. Part 2: treatment approaches." Annals of Internal Medicine 133: 9: 726-737.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0003-4819 | volume = 133 | pages = 726-737 | last = Felson | first = D. T. | coauthors = Lawrence, R. C., Hochberg, M. C., McAlindon, T., Dieppe, P. A., Minor, M. A., Blair, S. N., Berman, B. M., Fries, J. F., Weinberger, M., Lorig, K. R., Jacobs, J. J., Goldberg, V. | title = Osteoarthritis: new insights. Part 2: treatment approaches | journal = Annals of Internal Medicine | date = 11/7/2000 | pmid = | pmc = }} </ref>