Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts
Language: 
English
Abstract: 

The lifespan of human foreskin fibroblasts (HFF5), cultured under standard in vitro conditions (including ambient atmospheric oxygen tension), was extended slightly by expression of exogenous mortalin (mot-2)/mthsp70/Grp75, but not by the catalytic subunit of telomerase, hTERT. Together, mot-2 and hTERT permitted bypass of senescence, a substantial extension of lifespan, and possibly immortalization. This is the first demonstration that mot-2 and telomerase can cooperate in the immortalization process.

Author(s): 
Kaul, Sunil C.
Yaguchi, Tomoko
Taira, Kazunari
Reddel, Roger R.
Wadhwa, Renu
Item Type: 
Journal Article
Publication Title: 
Experimental Cell Research
Journal Abbreviation: 
Exp. Cell Res.
Publication Date: 
5/15/2003
Publication Year: 
2003
Pages: 
96-101
Volume: 
286
Issue: 
1
ISSN: 
0014-4827
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 12729798

Turabian/Chicago Citation

Sunil C. Kaul, Tomoko Yaguchi, Kazunari Taira, Roger R. Reddel and Renu Wadhwa. 5/15/2003. "Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts." Experimental Cell Research 286: 1: 96-101.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0014-4827 | volume = 286 | pages = 96-101 | last = Kaul | first = Sunil C. | coauthors = Yaguchi, Tomoko, Taira, Kazunari, Reddel, Roger R., Wadhwa, Renu | title = Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts | journal = Experimental Cell Research | date = 5/15/2003 | pmid = | pmc = }} </ref>