Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)
Language: 
English
Abstract: 

Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.

Author(s): 
Kaiser, Marcel
Wittlin, Sergio
Nehrbass-Stuedli, Angela
Dong, Yuxiang
Wang, Xiaofang
Hemphill, Andrew
Matile, Hugues
Brun, Reto
Vennerstrom, Jonathan L.
Item Type: 
Journal Article
Publication Title: 
Antimicrobial Agents and Chemotherapy
Journal Abbreviation: 
Antimicrob. Agents Chemother.
Publication Date: 
8/7/2015
Publication Year: 
2007
Pages: 
2991-2993
Volume: 
51
Issue: 
8
ISSN: 
0066-4804
DOI: 
10.1128/AAC.00225-07
Library Catalog: 
PubMed
Extra: 
PMID: 17562801 PMCID: PMC1932508

Turabian/Chicago Citation

Marcel Kaiser, Sergio Wittlin, Angela Nehrbass-Stuedli, Yuxiang Dong, Xiaofang Wang, Andrew Hemphill, Hugues Matile, Reto Brun and Jonathan L. Vennerstrom. 8/7/2015. "Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)." Antimicrobial Agents and Chemotherapy 51: 8: 2991-2993. 10.1128/AAC.00225-07.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1128/AAC.00225-07 | issn = 0066-4804 | volume = 51 | pages = 2991-2993 | last = Kaiser | first = Marcel | coauthors = Wittlin, Sergio, Nehrbass-Stuedli, Angela, Dong, Yuxiang, Wang, Xiaofang, Hemphill, Andrew, Matile, Hugues, Brun, Reto, Vennerstrom, Jonathan L. | title = Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160) | journal = Antimicrobial Agents and Chemotherapy | date = 8/7/2015 | pmid = | pmc = }} </ref>