Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm
Language: 
English
Short Title: 
Peroxisome proliferator-activated receptor-gamma
Abstract: 

The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) helps to translate 'what you eat' into 'what you are' because it allows dietary fatty acids (PPARgamma ligands) to modulate gene transcription. Treatments for diabetes include PPARgamma activators, as they sensitize the body to insulin. Our understanding of PPARgamma function has recently been enhanced by a flurry of human and mouse genetic studies, and the characterization of new PPARgamma ligands. This insight has led us to propose that modulating PPARgamma activity, rather than activating it, might be the most effective strategy for treating metabolic disorders, as this will improve glucose homeostasis while preventing adipogenesis.

Author(s): 
Cock, Terrie-Anne
Houten, Sander M.
Auwerx, Johan
Item Type: 
Journal Article
Publication Title: 
EMBO reports
Journal Abbreviation: 
EMBO Rep.
Publication Date: 
2004-02
Publication Year: 
2004
Pages: 
142-147
Volume: 
5
Issue: 
2
ISSN: 
1469-221X
DOI: 
10.1038/sj.embor.7400082
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 14755307 PMCID: PMC1298993

Turabian/Chicago Citation

Terrie-Anne Cock, Sander M. Houten and Johan Auwerx. 2004-02. "Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm." EMBO reports 5: 2: 142-147. 10.1038/sj.embor.7400082.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/sj.embor.7400082 | issn = 1469-221X | volume = 5 | pages = 142-147 | last = Cock | first = Terrie-Anne | coauthors = Houten, Sander M., Auwerx, Johan | title = Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm | journal = EMBO reports | date = 2004-02 | pmid = | pmc = }} </ref>