Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease
Language: 
English
Short Title: 
Perspectives in dermatopathology
Abstract: 

Shortening of telomeres occurs with cell proliferation and correlates well with ageing in humans. Telomerase is a ribonucleoprotein, and is the body's most widely studied mechanism for extension of telomeres to circumvent cellular ageing. Telomerase levels remain at low or unmeasurable levels in most somatic cell populations with only a few exceptions. However, in transformed cell populations, upregulation of telomerase or some other mechanism for telomere extension is required for immortality. The telomere-telomerase system has been proposed to be an adaptation of organisms with prolonged lifespan to avoid malignant tumors, at the cost of the cellular dysfunctions associated with the aged phenotype. Therapies to modulate telomere length and telomerase levels hold promise for therapy of cancer and ageing as well as for genetic conditions that predispose to an aged phenotype.

Author(s): 
Smith, K. J.
Germain, M.
Skelton, H.
Item Type: 
Journal Article
Publication Title: 
Journal of Cutaneous Pathology
Journal Abbreviation: 
J. Cutan. Pathol.
Publication Date: 
2000-01
Publication Year: 
2000
Pages: 
18-Feb
Volume: 
27
Issue: 
1
ISSN: 
0303-6987
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 10660126

Turabian/Chicago Citation

K. J. Smith, M. Germain and H. Skelton. 2000-01. "Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease." Journal of Cutaneous Pathology 27: 1: 18-Feb.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0303-6987 | volume = 27 | pages = 18-Feb | last = Smith | first = K. J. | coauthors = Germain, M., Skelton, H. | title = Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease | journal = Journal of Cutaneous Pathology | date = 2000-01 | pmid = | pmc = }} </ref>