Pharmacologic neuroimaging of the ontogeny of dopamine receptor function

Characterization of the ontogeny of the cerebral dopaminergic system is crucial for gaining a greater understanding of normal brain development and its alterations in response to drugs of abuse or conditions such as attention-deficit hyperactivity disorder. Pharmacological MRI (phMRI) was used to determine the response to dopamine transporter (DAT) blockers cocaine and methylphenidate (MPH), the dopamine releaser D-amphetamine (AMPH), the selective D1 agonist dihydrexidine, and the D2/D3 agonist quinpirole in young (<30 days old) and adult (>60 days old) rats. In adult rats, cocaine (0.5 mg/kg i.v.) or MPH (2 mg/kg) induced primarily positive cerebral blood volume (rCBV) changes in the dopaminergic circuitry, but negative rCBV changes in the young animals. Microdialysis measurements in the striatum showed that young rats have a smaller increase in extracellular dopamine in response to cocaine than adults. The young rats showed little rCBV response to the selective D1 agonist dihydrexidine in contrast to robust rCBV increases observed in the adults, whereas there was a similar negative rCBV response in the young and adult rats to the D2 agonist quinpirole. We also performed a meta-analysis of literature data on the development of D1 and D2 receptors and the DAT. These data suggest a predominance of D2-like over D1-like function between 20 and 30 days of age. These combined results suggested that the dopamine D1 receptor is functionally inhibited at young age.

Chen, Y. Iris
Choi, Ji-Kyung
Xu, Haibo
Ren, JiaQian
Andersen, Susan L.
Jenkins, Bruce G.
Item Type: 
Journal Article
Publication Title: 
Developmental Neuroscience
Journal Abbreviation: 
Dev. Neurosci.
Publication Date: 
Jul 2010
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 20523024 PMCID: PMC2919511

Turabian/Chicago Citation

Y. Iris Chen, Ji-Kyung Choi, Haibo Xu, JiaQian Ren, Susan L. Andersen and Bruce G. Jenkins. Jul 2010. "Pharmacologic neuroimaging of the ontogeny of dopamine receptor function." Developmental Neuroscience 32: 2: 125-138. 10.1159/000286215.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1159/000286215 | issn = 1421-9859 | volume = 32 | pages = 125-138 | last = Chen | first = Y. Iris | coauthors = Choi, Ji-Kyung, Xu, Haibo, Ren, JiaQian, Andersen, Susan L., Jenkins, Bruce G. | title = Pharmacologic neuroimaging of the ontogeny of dopamine receptor function | journal = Developmental Neuroscience | date = Jul 2010 | pmid = | pmc = }} </ref>