The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials
Language: 
English
Short Title: 
The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents
Abstract: 

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of economic and social burdens. The objective of this systematic review will be to evaluate the comparative efficacy and safety of pharmacological and non-pharmacological treatments in children and adolescents with ADHD. METHODS: Searches involving PubMed/MEDLINE and the Cochrane Database of Systematic Reviews will be used to identify related systematic reviews and relevant randomized trials. Search results will be supplemented by reports from the regulatory and health technology agencies, clinical trials registers and by data requested from trialists and/or pharmaceutical companies. We will consider studies evaluating pharmacological interventions (e.g. stimulants, non-stimulants, antidepressants), psychological interventions (e.g. behavioural interventions, cognitive training and neurofeedback) and complementary and alternative medicine interventions (e.g. dietary interventions, supplement with fatty acids, vitamins, minerals, aminoacids, herbal treatment, homeopathy, and mind-body interventions including massage, chiropractic, acupuncture, yoga, meditation, Tai chi). Eligible control conditions will be placebo, waitlist, no treatment and usual care. Randomized controlled trials of a minimum of 3 weeks duration will be included. The primary outcomes of interest will be the proportion of patients who responded to treatment and who dropped out of the allocated treatment, respectively. Secondary outcomes will include treatment discontinuation due to adverse events, as well as the occurrences of serious adverse events and specific adverse events (decreased weight, anorexia, insomnia and sleep disturbances, anxiety, syncope and cardiovascular events). Two reviewers will independently screen references identified by the literature search, as well as potentially relevant full-text articles in duplicate. Data will be abstracted and risk of bias will be appraised by two team members independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. Random-effects pairwise meta-analyses and Bayesian network meta-analyses will be conducted where appropriate. DISCUSSION: This systematic review and network meta-analysis will compare the efficacy and safety of treatments used for ADHD in children and adolescents. The findings will assist patients, clinicians and healthcare providers to make evidence-based decisions regarding treatment selection. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42014015008 .

Author(s): 
Catalá-López, Ferrán
Hutton, Brian
Núñez-Beltrán, Amparo
Mayhew, Alain D.
Page, Matthew J.
Ridao, Manuel
Tobías, Aurelio
Catalá, Miguel A.
Tabarés-Seisdedos, Rafael
Moher, David
Item Type: 
Journal Article
Publication Title: 
Systematic Reviews
Journal Abbreviation: 
Syst Rev
Publication Date: 
2/27/2015
Publication Year: 
2015
Pages: 
19
Volume: 
4
ISSN: 
2046-4053
DOI: 
10.1186/s13643-015-0005-7
Library Catalog: 
PubMed
Extra: 
PMID: 25875125 PMCID: PMC4357151

Turabian/Chicago Citation

Ferrán Catalá-López, Brian Hutton, Amparo Núñez-Beltrán, Alain D. Mayhew, Matthew J. Page, Manuel Ridao, Aurelio Tobías, Miguel A. Catalá, Rafael Tabarés-Seisdedos and David Moher. 2/27/2015. "The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials." Systematic Reviews 4: 19. 10.1186/s13643-015-0005-7.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1186/s13643-015-0005-7 | issn = 2046-4053 | volume = 4 | pages = 19 | last = Catalá-López | first = Ferrán | coauthors = Hutton, Brian, Núñez-Beltrán, Amparo, Mayhew, Alain D., Page, Matthew J., Ridao, Manuel, Tobías, Aurelio, Catalá, Miguel A., Tabarés-Seisdedos, Rafael, Moher, David | title = The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials | journal = Systematic Reviews | date = 2/27/2015 | pmid = | pmc = }} </ref>