Pharmacological lifespan extension of invertebrates
Language: 
English
Abstract: 

There is considerable interest in identifying small, drug-like compounds that slow aging in multiple species, particularly in mammals. Such compounds may prove to be useful in treating and retarding age-related disease in humans. Just as invertebrate models have been essential in helping us understand the genetic pathways that control aging, these model organisms are also proving valuable in discovering chemical compounds that influence longevity. The nematode Caenorhabditis elegans has numerous advantages for such studies including its short lifespan and has been exploited by a number of investigators to find compounds that impact aging. Here, we summarize the progress being made in identifying compounds that extend the lifespan of invertebrates, and introduce the challenges we face in translating this research into human therapies.

Author(s): 
Lucanic, Mark
Lithgow, Gordon J.
Alavez, Silvestre
Item Type: 
Journal Article
Publication Title: 
Ageing Research Reviews
Journal Abbreviation: 
Ageing Res. Rev.
Publication Date: 
2013-01
Publication Year: 
2013
Pages: 
445-458
Volume: 
12
Issue: 
1
ISSN: 
1872-9649
DOI: 
10.1016/j.arr.2012.06.006
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22771382 PMCID: PMC3552093

Turabian/Chicago Citation

Mark Lucanic, Gordon J. Lithgow and Silvestre Alavez. 2013-01. "Pharmacological lifespan extension of invertebrates." Ageing Research Reviews 12: 1: 445-458. 10.1016/j.arr.2012.06.006.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.arr.2012.06.006 | issn = 1872-9649 | volume = 12 | pages = 445-458 | last = Lucanic | first = Mark | coauthors = Lithgow, Gordon J., Alavez, Silvestre | title = Pharmacological lifespan extension of invertebrates | journal = Ageing Research Reviews | date = 2013-01 | pmid = | pmc = }} </ref>