A polyherbal ayurvedic drug--Indukantha Ghritha as an adjuvant to cancer chemotherapy via immunomodulation
Language: 
English
Abstract: 

Indukantha Ghritha (IG) is a polyherbal preparation consisting of 17 plant components widely prescribed by ayurvedic physicians for various ailments. Though it is a known ayurvedic drug, no attempt has been made to scientifically validate its mechanism of action. Preliminary studies in our laboratory showed IG to possess considerable immunomodulatory effects with a Th1 type of immune response. In this regard, we attempted to elucidate its role as an adjuvant to cancer chemotherapy. BALB/c mice were administered IG, for a period of 14 days and parameters such as Hb, total and differential WBC count, bone marrow cellularity, lymphocyte proliferation and function, macrophage phagocytosis and tumor remission were studied. Administration of IG could inhibit tumor development in mice challenged with Dalton's lymphoma ascites. IG-induced leukopoiesis and enhanced median survival time as well as life span in tumor bearing animals. Macrophage phagocytic capacity was also elevated. Flow cytometric analysis of lymphocyte subsets and MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium salt] assay for lymphocyte proliferation, yielded promising results which reinforces its use as an adjuvant to cancer chemotherapy. The polyherbal drug could reverse cyclophosphamide-induced myelosuppression in control tumor bearing animals significantly to values near or above normal levels. These results demonstrate the potential of IG, especially in several immunosuppressed conditions and patients suffering from leukopenia as a consequence of cancer chemotherapy.

Author(s): 
George, Suraj K.
Rajesh, R.
Kumar S, Sunil
Sulekha, B.
Balaram, Prabha
Item Type: 
Journal Article
Publication Title: 
Immunobiology
Journal Abbreviation: 
Immunobiology
Publication Date: 
2008
Publication Year: 
2008
Pages: 
641-649
Volume: 
213
Issue: 
8
ISSN: 
0171-2985
DOI: 
10.1016/j.imbio.2008.02.004
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18765169

Turabian/Chicago Citation

Suraj K. George, R. Rajesh, Sunil Kumar S, B. Sulekha and Prabha Balaram. 2008. "A polyherbal ayurvedic drug--Indukantha Ghritha as an adjuvant to cancer chemotherapy via immunomodulation." Immunobiology 213: 8: 641-649. 10.1016/j.imbio.2008.02.004.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.imbio.2008.02.004 | issn = 0171-2985 | volume = 213 | pages = 641-649 | last = George | first = Suraj K. | coauthors = Rajesh, R., Kumar S, Sunil, Sulekha, B., Balaram, Prabha | title = A polyherbal ayurvedic drug--Indukantha Ghritha as an adjuvant to cancer chemotherapy via immunomodulation | journal = Immunobiology | date = 2008 | pmid = | pmc = }} </ref>