Polymorphic variation in the epigenetic gene DNMT3B modulates the environmental impact on cognitive ability: a twin study
Language: 
English
Short Title: 
Polymorphic variation in the epigenetic gene DNMT3B modulates the environmental impact on cognitive ability
Abstract: 

BACKGROUND: Though cognitive abilities in adulthood are largely influenced by individual genetic background, they have also been shown to be importantly influenced by environmental factors. Some of these influences are mediated by epigenetic mechanisms. Accordingly, polymorphic variants in the epigenetic gene DNMT3B have been linked to neurocognitive performance. Since monozygotic (MZ) twins may show larger or smaller intrapair phenotypic differences depending on whether their genetic background is more or less sensitive to environmental factors, a twin design was implemented to determine if particular polymorphisms in the DNMT3B gene may be linked to a better (worse) response to enriched (deprived) environmental factors. METHODS: Applying the variability gene methodology in a sample of 54 healthy MZ twin pairs (108 individuals) with no lifetime history of psychopathology, two DNMT3B polymorphisms were analyzed in relation to their intrapair differences for either intellectual quotient (IQ) or working memory performance. RESULTS: MZ twin pairs with the CC genotype for rs406193 SNP showed statistically significant larger intrapair differences in IQ than CT pairs. CONCLUSIONS: Results suggest that DNMT3B polymorphisms may explain variability in the IQ response to either enriched or impoverished environmental conditions. Accordingly, the applied methodology is shown as a potentially valuable tool for determining genetic markers of cognitive plasticity. Further research is needed to confirm this specific result and to expand on other putative genetic markers of environmental sensitivity.

Author(s): 
CÛrdova-Palomera, A.
FatjÛ-Vilas, M.
Kebir, O.
GastÛ, C.
Krebs, M. O.
FaÒan·s, L.
Item Type: 
Journal Article
Publication Title: 
European Psychiatry: The Journal of the Association of European Psychiatrists
Journal Abbreviation: 
Eur. Psychiatry
Publication Date: 
2015-02
Publication Year: 
2015
Pages: 
303-308
Volume: 
30
Issue: 
2
ISSN: 
1778-3585
DOI: 
10.1016/j.eurpsy.2014.11.011
Library Catalog: 
PubMed
Extra: 
PMID: 25530201

Turabian/Chicago Citation

A. CÛrdova-Palomera, M. FatjÛ-Vilas, O. Kebir, C. GastÛ, M. O. Krebs and L. FaÒan·s. 2015-02. "Polymorphic variation in the epigenetic gene DNMT3B modulates the environmental impact on cognitive ability: a twin study." European Psychiatry: The Journal of the Association of European Psychiatrists 30: 2: 303-308. 10.1016/j.eurpsy.2014.11.011.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.eurpsy.2014.11.011 | issn = 1778-3585 | volume = 30 | pages = 303-308 | last = CÛrdova-Palomera | first = A. | coauthors = FatjÛ-Vilas, M., Kebir, O., GastÛ, C., Krebs, M. O., FaÒan·s, L. | title = Polymorphic variation in the epigenetic gene DNMT3B modulates the environmental impact on cognitive ability: a twin study | journal = European Psychiatry: The Journal of the Association of European Psychiatrists | date = 2015-02 | pmid = | pmc = }} </ref>