Polyphenol extracts from Punica granatum and Terminalia chebula are anti-inflammatory and increase the survival rate of chickens challenged with Escherichia coli
Language: 
English
Abstract: 

Avian pathogenic Escherichia coli (APEC) causes inflammation in multiple organs of chickens called avian colibacillosis, and results in serious economic loss to the chicken industry. Polyphenolic compounds possess a wide range of physiological activities that may contribute to their beneficial effects against inflammation-related diseases. In this study, the curative effect and mechanism of action of the polyphenolic extracts from Punica granatum L. and Terminalia chebula Retz. in chickens challenged with APEC were studied. Specific-pathogen-free white Leghorn chickens (males, 21-d old) were challenged with APEC and then given oral administration of extracts of P. granatum and T. chebula. The extracts decreased the morbidity and inflammation induced by APEC. Data from quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay showed that the extracts of P. granatum and T. chebula polyphenols (GCP) reversed the over-expression genes of the Toll-like receptor (TLR) 2, 4, and 5, down-regulated the activation of nuclear factor-kappa B signal transduction pathways, and inhibited the production of pro-inflammatory cytokines. Naturally occurring GCP may be a potential alternative medicine for the prevention or treatment of avian colibacillosis.

Author(s): 
Zhong, Xinlu
Shi, Yaran
Chen, Jiajia
Xu, Jianqing
Wang, Lei
Beier, Ross C.
Hou, Xiaolin
Liu, Fenghua
Item Type: 
Journal Article
Publication Title: 
Biological & Pharmaceutical Bulletin
Journal Abbreviation: 
Biol. Pharm. Bull.
Publication Date: 
2014
Publication Year: 
2014
Pages: 
1575-1582
Volume: 
37
Issue: 
10
ISSN: 
1347-5215
Library Catalog: 
PubMed
Extra: 
PMID: 25273385

Turabian/Chicago Citation

Xinlu Zhong, Yaran Shi, Jiajia Chen, Jianqing Xu, Lei Wang, Ross C. Beier, Xiaolin Hou and Fenghua Liu. 2014. "Polyphenol extracts from Punica granatum and Terminalia chebula are anti-inflammatory and increase the survival rate of chickens challenged with Escherichia coli." Biological & Pharmaceutical Bulletin 37: 10: 1575-1582.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1347-5215 | volume = 37 | pages = 1575-1582 | last = Zhong | first = Xinlu | coauthors = Shi, Yaran, Chen, Jiajia, Xu, Jianqing, Wang, Lei, Beier, Ross C., Hou, Xiaolin, Liu, Fenghua | title = Polyphenol extracts from Punica granatum and Terminalia chebula are anti-inflammatory and increase the survival rate of chickens challenged with Escherichia coli | journal = Biological & Pharmaceutical Bulletin | date = 2014 | pmid = | pmc = }} </ref>