Pomegranate flower: a unique traditional antidiabetic medicine with dual PPAR-alpha/-gamma activator properties
Language: 
English
Short Title: 
Pomegranate flower
Abstract: 

PPARs are transcription factors belonging to the superfamily of nuclear receptors. PPAR-alpha is involved in the regulation of fatty acid (FA) uptake and oxidation, inflammation and vascular function, while PPAR-gamma participates in FA uptake and storage, glucose homeostasis and inflammation. The PPARs are thus major regulators of lipid and glucose metabolism. Synthetic PPAR-alpha or PPAR-gamma agonists have been widely used in the treatment of dyslipidaemia, hyperglycaemia and their complications. However, they are associated with an incidence of adverse events. Given the favourable metabolic effects of both PPAR-alpha and PPAR-gamma activators, as well as their potential to modulate vascular disease, combined PPAR-alpha/-gamma activation has recently emerged as a promising concept, leading to the development of mixed PPAR-alpha/-gamma activators. However, some major side effects associated with the synthetic dual activators have been reported. It is unclear whether this is a specific effect of the particular synthetic compounds or a class effect. To date, a medication that may combine the beneficial metabolic effects of PPAR-alpha and PPAR-gamma activation with fewer undesirable side effects has not been successfully developed. Pomegranate plant parts are used traditionally for the treatment of various disorders. However, only pomegranate flower has been prescribed in Unani and Ayurvedic medicines for the treatment of diabetes. This review provides a new understanding of the dual PPAR-alpha/-gamma activator properties of pomegranate flower in the potential treatment of diabetes and its associated complications.

Author(s): 
Li, Yuhao
Qi, Yanfei
Huang, Tom H. W.
Yamahara, Johji
Roufogalis, Basil D.
Item Type: 
Journal Article
Publication Title: 
Diabetes, Obesity & Metabolism
Journal Abbreviation: 
Diabetes Obes Metab
Publication Date: 
Jan 2008
Publication Year: 
2008
Pages: 
10-17
Volume: 
10
Issue: 
1
ISSN: 
1463-1326
DOI: 
10.1111/j.1463-1326.2007.00708.x
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18095947

Turabian/Chicago Citation

Yuhao Li, Yanfei Qi, Tom H. W. Huang, Johji Yamahara and Basil D. Roufogalis. Jan 2008. "Pomegranate flower: a unique traditional antidiabetic medicine with dual PPAR-alpha/-gamma activator properties." Diabetes, Obesity & Metabolism 10: 1: 10-17. 10.1111/j.1463-1326.2007.00708.x.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1111/j.1463-1326.2007.00708.x | issn = 1463-1326 | volume = 10 | pages = 10-17 | last = Li | first = Yuhao | coauthors = Qi, Yanfei, Huang, Tom H. W., Yamahara, Johji, Roufogalis, Basil D. | title = Pomegranate flower: a unique traditional antidiabetic medicine with dual PPAR-alpha/-gamma activator properties | journal = Diabetes, Obesity & Metabolism | date = Jan 2008 | pmid = | pmc = }} </ref>