Potential role of ginseng in the treatment of colorectal cancer
Language: 
English
Abstract: 

Colorectal cancer remains one of the most prevalent cancer and a leading cause of cancer related death in the US. Many currently used chemotherapeutic agents are derived from botanicals. Identifying herbal sources, including those from ginseng family, to develop better anti-cancer therapies remains an essential step in advancing the treatment of the cancer. In this article, potential roles of ginseng herbs, especially American ginseng and notoginseng, in colorectal cancer therapeutics are presented. The major pharmacologically active constituents of ginsengs are ginsenosides, which can be mainly classified as protopanaxadiol and protopanaxatriol groups. Structure-activity relationship between their chemical structures and pharmacological activities are discussed. In addition, various steaming temperature and time treatment of the ginseng herbs can change ginsenoside profiles, and enhance their anti-cancer activities. This heat treatment process may increase the role of ginseng in treating colorectal cancer.

Author(s): 
Wang, Chong-Zhi
Yuan, Chun-Su
Item Type: 
Journal Article
Publication Title: 
The American Journal of Chinese Medicine
Journal Abbreviation: 
Am. J. Chin. Med.
Publication Date: 
2008
Publication Year: 
2008
Pages: 
1019-1028
Volume: 
36
Issue: 
6
ISSN: 
0192-415X
DOI: 
10.1142/S0192415X08006545
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 19051332 PMCID: PMC2676850

Turabian/Chicago Citation

Chong-Zhi Wang and Chun-Su Yuan. 2008. "Potential role of ginseng in the treatment of colorectal cancer." The American Journal of Chinese Medicine 36: 6: 1019-1028. 10.1142/S0192415X08006545.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1142/S0192415X08006545 | issn = 0192-415X | volume = 36 | pages = 1019-1028 | last = Wang | first = Chong-Zhi | coauthors = Yuan, Chun-Su | title = Potential role of ginseng in the treatment of colorectal cancer | journal = The American Journal of Chinese Medicine | date = 2008 | pmid = | pmc = }} </ref>