Potentiating effects of L-type Ca(2+) channel blockers on pentobarbital-induced hypnosis are influenced by serotonergic system
Language: 
English
Abstract: 

In order to elucidate the mechanism(s) behind the interactions between barbiturates and Ca(2+) antagonists, the effects of three structurally diverse types of Ca(2+) antagonists combined or not with 5-HT on pentobarbital-induced hypnosis in mice were investigated. The results showed that dihydropyridine derivative nifedipine (10.0 and 20.0 mg/kg, p.o.) and other types of Ca(2+) antagonist, verapamil (5.0 and 10.0 mg/kg, p.o.) and diltiazem (2.5, 5.0 and 10.0 mg/kg, p.o.) increased both the sleeping time in hypnotic dosage of pentobarbital (45 mg/kg, i.p.) treated mice and the rate of sleep onset in the sub-hypnotic dosage of pentobarbital (28 mg/kg, i.p.) treated mice in a dose-dependent manner, respectively, and these effects were significantly augmented by 5-hydroxytryptophan (5-HTP), the immediate precursor of 5-hydroxytryptamine (5-HT). Pretreatment with p-chlorophenylalanine (PCPA, 300 mg/kg, s.c.), an inhibitor of tryptophan hydroxylase, significantly decreased pentobarbital-induced sleeping time and nifedipine (10.0 mg/kg, p.o.), verapamil (5.0 mg/kg, p.o.) and diltiazem (2.5 mg/kg, p.o.) abolished this effect. From these results, it should be presumed that the augmentative effect of L-type Ca(2+) channel blockers on pentobarbital-induced sleep may be influenced by serotonergic system.

Author(s): 
Zhao, X.
Cui, X.-Y.
Chu, Q.-P.
Chen, B.-Q.
Wang, X.-M.
Lin, Z.-B.
Li, X.-J.
Ku, B.-S.
Zhang, Y.-H.
Item Type: 
Journal Article
Publication Title: 
Journal of Neural Transmission (Vienna, Austria: 1996)
Journal Abbreviation: 
J Neural Transm
Publication Date: 
10/6/2015
Publication Year: 
2006
Pages: 
1395-1402
Volume: 
113
Issue: 
10
ISSN: 
0300-9564
DOI: 
10.1007/s00702-005-0422-1
Library Catalog: 
PubMed
Extra: 
PMID: 16465463

Turabian/Chicago Citation

X. Zhao, X.-Y. Cui, Q.-P. Chu, B.-Q. Chen, X.-M. Wang, Z.-B. Lin, X.-J. Li, B.-S. Ku and Y.-H. Zhang. 10/6/2015. "Potentiating effects of L-type Ca(2+) channel blockers on pentobarbital-induced hypnosis are influenced by serotonergic system." Journal of Neural Transmission (Vienna, Austria: 1996) 113: 10: 1395-1402. 10.1007/s00702-005-0422-1.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s00702-005-0422-1 | issn = 0300-9564 | volume = 113 | pages = 1395-1402 | last = Zhao | first = X. | coauthors = Cui, X.-Y., Chu, Q.-P., Chen, B.-Q., Wang, X.-M., Lin, Z.-B., Li, X.-J., Ku, B.-S., Zhang, Y.-H. | title = Potentiating effects of L-type Ca(2+) channel blockers on pentobarbital-induced hypnosis are influenced by serotonergic system | journal = Journal of Neural Transmission (Vienna, Austria: 1996) | date = 10/6/2015 | pmid = | pmc = }} </ref>