Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats
Language: 
English
Abstract: 

Terminalia belerica Roxb. is one of the oldest medicinal herb of India, is an ingredient of Indian Ayurvedic drug 'triphala' used for the treatment of digestion and liver disorders. Present study is aimed to evaluate the protective effect of Terminalia belerica fruit extract and its active principle, gallic acid (3,4,5-trihydroxybenzoic acid) at different doses against carbon tetrachloride intoxication. Toxicant caused significant increase in the activities of serum transaminases and serum alkaline phosphatase. Hepatic lipid peroxidation level increased significantly whereas significant depletion was observed in reduced glutathione level after carbon tetrachloride administration. A minimum elevation was found in protein content on the contrary a significant fall was observed in glycogen content of liver and kidney after toxicant exposure. Activities of adenosine triphosphatase and succinic dehydrogenase inhibited significantly in both the organs after toxicity. Treatment with TB extract (200, 400 and 800mg/kg, p.o.) and gallic acid (50, 100 and 200mg/kg, p.o.) showed dose-dependent recovery in all these biochemical parameters but the effect was more pronounced with gallic acid. Thus it may be concluded that 200mg/kg dose of gallic acid was found to be most effective against carbon tetrachloride induced liver and kidney damage.

Author(s): 
Jadon, Anjana
Bhadauria, Monika
Shukla, Sangeeta
Item Type: 
Journal Article
Publication Title: 
Journal of Ethnopharmacology
Journal Abbreviation: 
J Ethnopharmacol
Publication Date: 
Jan 19, 2007
Publication Year: 
2007
Pages: 
214-218
Volume: 
109
Issue: 
2
ISSN: 
0378-8741
DOI: 
10.1016/j.jep.2006.07.033
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 17049775

Turabian/Chicago Citation

Anjana Jadon, Monika Bhadauria and Sangeeta Shukla. Jan 19, 2007. "Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats." Journal of Ethnopharmacology 109: 2: 214-218. 10.1016/j.jep.2006.07.033.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jep.2006.07.033 | issn = 0378-8741 | volume = 109 | pages = 214-218 | last = Jadon | first = Anjana | coauthors = Bhadauria, Monika, Shukla, Sangeeta | title = Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats | journal = Journal of Ethnopharmacology | date = Jan 19, 2007 | pmid = | pmc = }} </ref>