Psychobiology and molecular genetics of resilience
Language: 
English
Abstract: 

Every individual experiences stressful life events. In some cases acute or chronic stress leads to depression and other psychiatric disorders, but most people are resilient to such effects. Recent research has begun to identify the environmental, genetic, epigenetic and neural mechanisms that underlie resilience, and has shown that resilience is mediated by adaptive changes in several neural circuits involving numerous neurotransmitter and molecular pathways. These changes shape the functioning of the neural circuits that regulate reward, fear, emotion reactivity and social behaviour, which together are thought to mediate successful coping with stress.

Author(s): 
Feder, Adriana
Nestler, Eric J.
Charney, Dennis S.
Item Type: 
Journal Article
Publication Title: 
Nature Reviews. Neuroscience
Journal Abbreviation: 
Nat. Rev. Neurosci.
Publication Date: 
2009-06
Publication Year: 
2009
Pages: 
446-457
Volume: 
10
Issue: 
6
ISSN: 
1471-0048
DOI: 
10.1038/nrn2649
Library Catalog: 
PubMed
Extra: 
PMID: 19455174 PMCID: PMC2833107

Turabian/Chicago Citation

Adriana Feder, Eric J. Nestler and Dennis S. Charney. 2009-06. "Psychobiology and molecular genetics of resilience." Nature Reviews. Neuroscience 10: 6: 446-457. 10.1038/nrn2649.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/nrn2649 | issn = 1471-0048 | volume = 10 | pages = 446-457 | last = Feder | first = Adriana | coauthors = Nestler, Eric J., Charney, Dennis S. | title = Psychobiology and molecular genetics of resilience | journal = Nature Reviews. Neuroscience | date = 2009-06 | pmid = | pmc = }} </ref>