The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
Language: 
English
Abstract: 

Telomere length (TL) has been proposed as a marker of mitotic cell age and as a general index of human organismic aging. Short absolute leukocyte telomere length has been linked to cardiovascular-related morbidity and mortality. Our aim was to test whether the rate of change in leukocyte TL is related to mortality in a healthy elderly cohort. We examined a subsample of 236 randomly selected Caucasian participants from the MacArthur Health Aging Study (aged 70 to 79 years). DNA samples from baseline and 2.5 years later were assayed for mean TL of leukocytes. Percent change in TL was calculated as a measure of TL change (TLC). Associations between TL and TLC with 12-year overall and cardiovascular mortality were assessed. Over the 2.5 year period, 46% of the study participants showed maintenance of mean bulk TL, whereas 30% showed telomere shortening, and, unexpectedly, 24% showed telomere lengthening. For women, short baseline TL was related to greater mortality from cardiovascular disease (OR = 2.3; 95% CI: 1.0 - 5.3). For men, TLC (specifically shortening), but not baseline TL, was related to greater cardiovascular mortality, OR = 3.0 (95% CI: 1.1 - 8.2). This is the first demonstration that rate of telomere length change (TLC) predicts mortality and thus may be a useful prognostic factor for longevity.

Author(s): 
Epel, Elissa S.
Merkin, Sharon Stein
Cawthon, Richard
Blackburn, Elizabeth H.
Adler, Nancy E.
Pletcher, Mark J.
Seeman, Teresa E.
Item Type: 
Journal Article
Publication Title: 
Aging
Journal Abbreviation: 
Aging (Albany NY)
Publication Date: 
2009-01
Publication Year: 
2009
Pages: 
81-88
Volume: 
1
Issue: 
1
ISSN: 
1945-4589
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20195384 PMCID: PMC2830080

Turabian/Chicago Citation

Elissa S. Epel, Sharon Stein Merkin, Richard Cawthon, Elizabeth H. Blackburn, Nancy E. Adler, Mark J. Pletcher and Teresa E. Seeman. 2009-01. "The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men." Aging 1: 1: 81-88.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1945-4589 | volume = 1 | pages = 81-88 | last = Epel | first = Elissa S. | coauthors = Merkin, Sharon Stein, Cawthon, Richard, Blackburn, Elizabeth H., Adler, Nancy E., Pletcher, Mark J., Seeman, Teresa E. | title = The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men | journal = Aging | date = 2009-01 | pmid = | pmc = }} </ref>